Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population
Abstract Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 (GNL3) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the c...
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| Format: | Article |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20287-4 |
| _version_ | 1811253763370909696 |
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| author | Xi Wang Lin Xiao Zhiyuan Wang Liqiang Zhi Qiang Li |
| author_facet | Xi Wang Lin Xiao Zhiyuan Wang Liqiang Zhi Qiang Li |
| author_sort | Xi Wang |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 (GNL3) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA (P = 4.32 × 10–5). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade (P < 0.01) and categorized pain scores (P < 0.01). Significant eQTL signals for rs11177 on GNL3 in multiple types of human tissues were also identified in GTEx database. Our results have established the link between GNL3 gene and susceptibility of hand OA. |
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| id | doaj.art-cdb7251f402b4ab4939e80cefa410a29 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:56:05Z |
| publishDate | 2022-09-01 |
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| spelling | doaj.art-cdb7251f402b4ab4939e80cefa410a292022-12-22T03:24:14ZengNature PortfolioScientific Reports2045-23222022-09-011211610.1038/s41598-022-20287-4Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese populationXi Wang0Lin Xiao1Zhiyuan Wang2Liqiang Zhi3Qiang Li4Department of Knee Joint Surgery, Xi’an Honghui HospitalDepartment of Knee Joint Surgery, Xi’an Honghui HospitalDepartment of Knee Joint Surgery, Xi’an Honghui HospitalDepartment of Knee Joint Surgery, Xi’an Honghui HospitalDepartment of Hand Surgery, Xi’an Honghui HospitalAbstract Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 (GNL3) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine the contribution of GNL3 gene polymorphisms to the risk of hand OA and its related clinical features. A total of 3387 study participants including 1160 patients with hand OA and 2227 controls were recruited in this study. Eleven SNPs in GNL3 gene were selected for genotyping. Genetic association signals were examined using Plink. Relationships between significant SNPs and clinical features of hand OA were also explored. SNP rs11177 was found to be strongly associated with susceptibility of hand OA (P = 4.32 × 10–5). The minor allele of rs11177 was associated with increased susceptibility of hand OA. In addition, significant associations were also identified between genotypes of rs11177 and clinical features of hand OA patients including K-L grade (P < 0.01) and categorized pain scores (P < 0.01). Significant eQTL signals for rs11177 on GNL3 in multiple types of human tissues were also identified in GTEx database. Our results have established the link between GNL3 gene and susceptibility of hand OA.https://doi.org/10.1038/s41598-022-20287-4 |
| spellingShingle | Xi Wang Lin Xiao Zhiyuan Wang Liqiang Zhi Qiang Li Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population Scientific Reports |
| title | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population |
| title_full | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population |
| title_fullStr | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population |
| title_full_unstemmed | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population |
| title_short | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population |
| title_sort | common variants in gnl3 gene contributed the susceptibility of hand osteoarthritis in han chinese population |
| url | https://doi.org/10.1038/s41598-022-20287-4 |
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