Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4
Transient receptor potential melastatin 4 is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca<sup>2+</sup>-sensitive and permeable to monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions by regulating the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/1/81 |
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| author | Zsigmond Máté Kovács Csaba Dienes Tamás Hézső János Almássy János Magyar Tamás Bányász Péter P. Nánási Balázs Horváth Norbert Szentandrássy |
| author_facet | Zsigmond Máté Kovács Csaba Dienes Tamás Hézső János Almássy János Magyar Tamás Bányász Péter P. Nánási Balázs Horváth Norbert Szentandrássy |
| author_sort | Zsigmond Máté Kovács |
| collection | DOAJ |
| description | Transient receptor potential melastatin 4 is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca<sup>2+</sup>-sensitive and permeable to monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions by regulating the membrane potential and Ca<sup>2+</sup> homeostasis in both excitable and non-excitable cells. This part of the review discusses the pharmacological modulation of TRPM4 by listing, comparing, and describing both endogenous and exogenous activators and inhibitors of the ion channel. Moreover, other strategies used to study TRPM4 functions are listed and described. These strategies include siRNA-mediated silencing of TRPM4, dominant-negative TRPM4 variants, and anti-TRPM4 antibodies. TRPM4 is receiving more and more attention and is likely to be the topic of research in the future. |
| first_indexed | 2024-03-10T00:44:30Z |
| format | Article |
| id | doaj.art-cdb8f3d15fb8457387535b7f16ab4155 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T00:44:30Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-cdb8f3d15fb8457387535b7f16ab41552023-11-23T15:01:46ZengMDPI AGPharmaceuticals1424-82472022-01-011518110.3390/ph15010081Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4Zsigmond Máté Kovács0Csaba Dienes1Tamás Hézső2János Almássy3János Magyar4Tamás Bányász5Péter P. Nánási6Balázs Horváth7Norbert Szentandrássy8Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryTransient receptor potential melastatin 4 is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca<sup>2+</sup>-sensitive and permeable to monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions by regulating the membrane potential and Ca<sup>2+</sup> homeostasis in both excitable and non-excitable cells. This part of the review discusses the pharmacological modulation of TRPM4 by listing, comparing, and describing both endogenous and exogenous activators and inhibitors of the ion channel. Moreover, other strategies used to study TRPM4 functions are listed and described. These strategies include siRNA-mediated silencing of TRPM4, dominant-negative TRPM4 variants, and anti-TRPM4 antibodies. TRPM4 is receiving more and more attention and is likely to be the topic of research in the future.https://www.mdpi.com/1424-8247/15/1/81TRPM4SUR1CBAflufenamic acid9-phenanthrolsiRNA |
| spellingShingle | Zsigmond Máté Kovács Csaba Dienes Tamás Hézső János Almássy János Magyar Tamás Bányász Péter P. Nánási Balázs Horváth Norbert Szentandrássy Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4 Pharmaceuticals TRPM4 SUR1 CBA flufenamic acid 9-phenanthrol siRNA |
| title | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4 |
| title_full | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4 |
| title_fullStr | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4 |
| title_full_unstemmed | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4 |
| title_short | Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4 |
| title_sort | pharmacological modulation and patho physiological roles of trpm4 channel part 1 modulation of trpm4 |
| topic | TRPM4 SUR1 CBA flufenamic acid 9-phenanthrol siRNA |
| url | https://www.mdpi.com/1424-8247/15/1/81 |
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