Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell

Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell

NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of NRF2 in human breast cancer (BC) cells. The effect of FKBP4 appeared to be at protein level of NRF2 since it...

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Bibliographic Details
Main Authors: Hanchu Xiong, Zihan Chen, Baihua Lin, Bojian Xie, Xiaozhen Liu, Cong Chen, Zhaoqing Li, Yunlu Jia, Zhuazhua Wu, Min Yang, Yongshi Jia, Linbo Wang, Jichun Zhou, Xuli Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
FKBP4
NRF2
NR3C1
autophagy
Dendritic cell
Breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.745111/full

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