The functional roles of the circRNA/Wnt axis in cancer
Abstract CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-022-01582-0 |
| _version_ | 1828786655212863488 |
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| author | Chen Xue Ganglei Li Qiuxian Zheng Xinyu Gu Zhengyi Bao Juan Lu Lanjuan Li |
| author_facet | Chen Xue Ganglei Li Qiuxian Zheng Xinyu Gu Zhengyi Bao Juan Lu Lanjuan Li |
| author_sort | Chen Xue |
| collection | DOAJ |
| description | Abstract CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression. |
| first_indexed | 2024-12-12T00:16:23Z |
| format | Article |
| id | doaj.art-cdba5b33cce94bc3909b5e4e68d8e8c6 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-12T00:16:23Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-cdba5b33cce94bc3909b5e4e68d8e8c62022-12-22T00:44:51ZengBMCMolecular Cancer1476-45982022-05-0121112410.1186/s12943-022-01582-0The functional roles of the circRNA/Wnt axis in cancerChen Xue0Ganglei Li1Qiuxian Zheng2Xinyu Gu3Zhengyi Bao4Juan Lu5Lanjuan Li6State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang UniversityDepartment of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang UniversityAbstract CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.https://doi.org/10.1186/s12943-022-01582-0circRNAWntcancerBiomarkerMechanism |
| spellingShingle | Chen Xue Ganglei Li Qiuxian Zheng Xinyu Gu Zhengyi Bao Juan Lu Lanjuan Li The functional roles of the circRNA/Wnt axis in cancer Molecular Cancer circRNA Wnt cancer Biomarker Mechanism |
| title | The functional roles of the circRNA/Wnt axis in cancer |
| title_full | The functional roles of the circRNA/Wnt axis in cancer |
| title_fullStr | The functional roles of the circRNA/Wnt axis in cancer |
| title_full_unstemmed | The functional roles of the circRNA/Wnt axis in cancer |
| title_short | The functional roles of the circRNA/Wnt axis in cancer |
| title_sort | functional roles of the circrna wnt axis in cancer |
| topic | circRNA Wnt cancer Biomarker Mechanism |
| url | https://doi.org/10.1186/s12943-022-01582-0 |
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