Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit.
Objectives Pneumonia is one of the leading causes of death in the intensive care unit (ICU). Many biomarkers for predicted prognosis have been suggested; among these, procalcitonin (PCT) is known to increase in cases of bacterial infection. However, there have been many debates regarding whether PCT...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2019-06-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc034-01-02.pdf |
| _version_ | 1811255695248457728 |
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| author | Deok Hee Kim Hae Won Jung Hyung Koo Kang |
| author_facet | Deok Hee Kim Hae Won Jung Hyung Koo Kang |
| author_sort | Deok Hee Kim |
| collection | DOAJ |
| description | Objectives Pneumonia is one of the leading causes of death in the intensive care unit (ICU). Many biomarkers for predicted prognosis have been suggested; among these, procalcitonin (PCT) is known to increase in cases of bacterial infection. However, there have been many debates regarding whether PCT is an appropriate prognostic marker for pneumonia. Therefore, we investigated whether PCT can serve as a biomarker for pneumonia, and compared it with CURB-65, which is a known tool for predicting the prognosis of pneumonia. Methods Levels of PCT and CURB-65 scores were compared between 30-day non-survival (n = 30) and survival (n = 101) patients. Relationships between PCT and CURB-65 were determined by using linear regression analysis, as well as by using receiver operating characteristic (ROC) curve analysis and calculation of the area under the curve (AUC). High and low PCT groups were compared. Results High PCT and high CURB-65 score were positively associated with 30-day mortality. For the prediction of 30-day mortality, initial PCT and CURB-65 exhibited AUCs of 0.63 and 0.66; these were not significantly different (P = 0.132). We found that the high PCT group had a higher rate of initial treatment failure (91%, P = 0.004). Conclusions Initial PCT can be a prognostic biomarker for mortality in severe pneumonia, similar to the CURB-65 score. Initial high PCT was positively associated with initial treatment failure. |
| first_indexed | 2024-04-12T17:28:31Z |
| format | Article |
| id | doaj.art-cdbaca4e82d140e898ef1c34ffa8fda3 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 |
| language | English |
| last_indexed | 2024-04-12T17:28:31Z |
| publishDate | 2019-06-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-cdbaca4e82d140e898ef1c34ffa8fda32022-12-22T03:23:12ZengKosin University College of MedicineKosin Medical Journal2005-95312019-06-01341152310.7180/kmj.2019.34.1.1595Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit.Deok Hee Kim0Hae Won Jung1Hyung Koo Kang2Department of Pulmonology, Asan Choongmu Hospital, Asan, .KoreaDepartment of Cardiology, Daegu Catholic University Medical Center, Daegu, .KoreaDepartment of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, .KoreaObjectives Pneumonia is one of the leading causes of death in the intensive care unit (ICU). Many biomarkers for predicted prognosis have been suggested; among these, procalcitonin (PCT) is known to increase in cases of bacterial infection. However, there have been many debates regarding whether PCT is an appropriate prognostic marker for pneumonia. Therefore, we investigated whether PCT can serve as a biomarker for pneumonia, and compared it with CURB-65, which is a known tool for predicting the prognosis of pneumonia. Methods Levels of PCT and CURB-65 scores were compared between 30-day non-survival (n = 30) and survival (n = 101) patients. Relationships between PCT and CURB-65 were determined by using linear regression analysis, as well as by using receiver operating characteristic (ROC) curve analysis and calculation of the area under the curve (AUC). High and low PCT groups were compared. Results High PCT and high CURB-65 score were positively associated with 30-day mortality. For the prediction of 30-day mortality, initial PCT and CURB-65 exhibited AUCs of 0.63 and 0.66; these were not significantly different (P = 0.132). We found that the high PCT group had a higher rate of initial treatment failure (91%, P = 0.004). Conclusions Initial PCT can be a prognostic biomarker for mortality in severe pneumonia, similar to the CURB-65 score. Initial high PCT was positively associated with initial treatment failure.http://www.kosinmedj.org/upload/pdf/ksmc034-01-02.pdfcurb-65mortalitypneumoniaprocalcitoninprognosis |
| spellingShingle | Deok Hee Kim Hae Won Jung Hyung Koo Kang Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit. Kosin Medical Journal curb-65 mortality pneumonia procalcitonin prognosis |
| title | Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit. |
| title_full | Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit. |
| title_fullStr | Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit. |
| title_full_unstemmed | Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit. |
| title_short | Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit. |
| title_sort | prognostic value of procalcitonin in pneumonia among patients admitted to intensive care unit |
| topic | curb-65 mortality pneumonia procalcitonin prognosis |
| url | http://www.kosinmedj.org/upload/pdf/ksmc034-01-02.pdf |
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