The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart
In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was...
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2011-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103563N.pdf |
| _version_ | 1811202189176078336 |
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| author | Nabavi S.F. Nabavi S.M. Ebrahimzadeh M.A. Eslami Sh. Jafari N. Moghaddam Hajizadeh A. |
| author_facet | Nabavi S.F. Nabavi S.M. Ebrahimzadeh M.A. Eslami Sh. Jafari N. Moghaddam Hajizadeh A. |
| author_sort | Nabavi S.F. |
| collection | DOAJ |
| description | In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was used as a normal group; groups II and III were pretreated with curcumin intraperitoneally for 7 days prior to NaF intoxication. Group IV was pretreated with vitamin C, a standard antioxidant, intraperitoneally for 7 days prior to NaF intoxication and used as a positive control group. The animals in group V were intoxicated with NaF for the same time and used as a control group. There was a significant increase in lipid peroxidation along with a decrease in superoxide dismutase activity in the homogenates of tissues of the NaF-treated animals. Curcumin pretreatment in animals prior to fluoride intoxication normalized the levels of biochemical parameters measured. |
| first_indexed | 2024-04-12T02:34:42Z |
| format | Article |
| id | doaj.art-cdbc13129ed14a589c6309d192921a86 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-04-12T02:34:42Z |
| publishDate | 2011-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-cdbc13129ed14a589c6309d192921a862022-12-22T03:51:37ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642011-01-0163356356910.2298/ABS1103563NThe protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heartNabavi S.F.Nabavi S.M.Ebrahimzadeh M.A.Eslami Sh.Jafari N.Moghaddam Hajizadeh A.In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was used as a normal group; groups II and III were pretreated with curcumin intraperitoneally for 7 days prior to NaF intoxication. Group IV was pretreated with vitamin C, a standard antioxidant, intraperitoneally for 7 days prior to NaF intoxication and used as a positive control group. The animals in group V were intoxicated with NaF for the same time and used as a control group. There was a significant increase in lipid peroxidation along with a decrease in superoxide dismutase activity in the homogenates of tissues of the NaF-treated animals. Curcumin pretreatment in animals prior to fluoride intoxication normalized the levels of biochemical parameters measured.http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103563N.pdfCurcuminoxidative stresssodium fluorideenzymatic antioxidant |
| spellingShingle | Nabavi S.F. Nabavi S.M. Ebrahimzadeh M.A. Eslami Sh. Jafari N. Moghaddam Hajizadeh A. The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart Archives of Biological Sciences Curcumin oxidative stress sodium fluoride enzymatic antioxidant |
| title | The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart |
| title_full | The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart |
| title_fullStr | The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart |
| title_full_unstemmed | The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart |
| title_short | The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart |
| title_sort | protective effect of curcumin against sodium fluoride induced oxidative stress in rat heart |
| topic | Curcumin oxidative stress sodium fluoride enzymatic antioxidant |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103563N.pdf |
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