Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels

Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels

All vertebrate cells activate Cl– currents (ICl,swell) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1. However, apart from VRAC, the Ca2+-activated Cl– channel (CaCC) TMEM16A and the phospholipid scramblase and ion channel TME...

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Bibliographic Details
Main Authors: Raquel Centeio, Jiraporn Ousingsawat, Rainer Schreiber, Karl Kunzelmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
VRAC
CaCC
TMEM16 proteins
anoctamin
ANO1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.596879/full

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