Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies
Abstract. The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status. These intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2024-01-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002955 |
| _version_ | 1797341103016378368 |
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| author | Suki Ha Xiang Zhang Jun Yu Yuanyuan Ji |
| author_facet | Suki Ha Xiang Zhang Jun Yu Yuanyuan Ji |
| author_sort | Suki Ha |
| collection | DOAJ |
| description | Abstract. The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status. These intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis, metabolism, and immune response. The disruption of microbiota, known as dysbiosis, has been implicated in many intestinal diseases, including colorectal cancer (CRC). As the third most common cancer and the second leading cause of cancer-related death worldwide, CRC poses a significant health burden. There is an urgent need for novel interventions to reduce CRC incidence and improve clinical outcomes. Modulating the intestinal microbiota has emerged as a promising approach for CRC prevention and treatment. Current research efforts in CRC probiotics primarily focus on reducing the incidence of CRC, alleviating treatment-related side effects, and potentiating the efficacy of anticancer therapy, which is the key to successful translation to clinical practice. This paper aims to review the traditional probiotics and new interventions, such as next-generation probiotics and postbiotics, in the context of CRC. The underlying mechanisms of probiotic anti-cancer effects are also discussed, including the restoration of microbial composition, reinforcement of gut barrier integrity, induction of cancer cell apoptosis, inactivation of carcinogens, and modulation of host immune response. This paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and immunotherapy. Despite all the promising findings presented in studies, the evaluation of potential risks, optimization of delivery methods, and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation. |
| first_indexed | 2024-03-08T10:13:02Z |
| format | Article |
| id | doaj.art-cdc12690e8d34cb4ab053be6f2c6e023 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-08T10:13:02Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-cdc12690e8d34cb4ab053be6f2c6e0232024-01-29T07:00:38ZengWolters KluwerChinese Medical Journal0366-69992542-56412024-01-01137182010.1097/CM9.0000000000002955202401050-00003Probiotics intervention in colorectal cancer: From traditional approaches to novel strategiesSuki Ha0Xiang Zhang1Jun Yu2Yuanyuan JiInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaAbstract. The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status. These intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis, metabolism, and immune response. The disruption of microbiota, known as dysbiosis, has been implicated in many intestinal diseases, including colorectal cancer (CRC). As the third most common cancer and the second leading cause of cancer-related death worldwide, CRC poses a significant health burden. There is an urgent need for novel interventions to reduce CRC incidence and improve clinical outcomes. Modulating the intestinal microbiota has emerged as a promising approach for CRC prevention and treatment. Current research efforts in CRC probiotics primarily focus on reducing the incidence of CRC, alleviating treatment-related side effects, and potentiating the efficacy of anticancer therapy, which is the key to successful translation to clinical practice. This paper aims to review the traditional probiotics and new interventions, such as next-generation probiotics and postbiotics, in the context of CRC. The underlying mechanisms of probiotic anti-cancer effects are also discussed, including the restoration of microbial composition, reinforcement of gut barrier integrity, induction of cancer cell apoptosis, inactivation of carcinogens, and modulation of host immune response. This paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and immunotherapy. Despite all the promising findings presented in studies, the evaluation of potential risks, optimization of delivery methods, and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.http://journals.lww.com/10.1097/CM9.0000000000002955 |
| spellingShingle | Suki Ha Xiang Zhang Jun Yu Yuanyuan Ji Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies Chinese Medical Journal |
| title | Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies |
| title_full | Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies |
| title_fullStr | Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies |
| title_full_unstemmed | Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies |
| title_short | Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies |
| title_sort | probiotics intervention in colorectal cancer from traditional approaches to novel strategies |
| url | http://journals.lww.com/10.1097/CM9.0000000000002955 |
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