Molecular mechanisms of the Guizhi decoction on osteoarthritis based on an integrated network pharmacology and RNA sequencing approach with experimental validation

Molecular mechanisms of the Guizhi decoction on osteoarthritis based on an integrated network pharmacology and RNA sequencing approach with experimental validation

Background: Our aim was to determine the potential pharmacological mechanisms of the Guizhi decoction (GZD) in the treatment of osteoarthritis (OA) through an integrated approach of network pharmacological analyses, RNA sequencing (RNA-seq), and experimental validation.Methods: The quality control a...

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Bibliographic Details
Main Authors: Yan Chen, Yan Xue, Xuezong Wang, Ding Jiang, Qinguang Xu, Lin Wang, Yuxin Zheng, Ying Shi, Yuelong Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Genetics
Subjects:
Guizhi decoction
osteoarthritis
network pharmacology
RNA sequencing
TNF signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1079631/full

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