Newly diagnosed AIDS patient with cerebellar JC virus
We present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability. Neuroimaging and CSF studies revealed a diagnosis of progressive multifocal leukoencephalopathy (PML). Although t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221425092300166X |
| _version_ | 1797692077726760960 |
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| author | Sergio Alvarez-Mulett Eli Sepkowitz Douglas Sepkowitz |
| author_facet | Sergio Alvarez-Mulett Eli Sepkowitz Douglas Sepkowitz |
| author_sort | Sergio Alvarez-Mulett |
| collection | DOAJ |
| description | We present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability. Neuroimaging and CSF studies revealed a diagnosis of progressive multifocal leukoencephalopathy (PML). Although the patient’s human immunodeficiency virus (HIV) decreased considerably in response to anti-retroviral therapy, he continued to deteriorate clinically. Ultimately, the central nervous system (CNS) lesions, which were once centered in the cerebellum, became expansile throughout his posterior fossa. There are few reported cases of cerebellar PML in patients with AIDS. |
| first_indexed | 2024-03-12T02:22:30Z |
| format | Article |
| id | doaj.art-cdc558e2113346bc909ac8ac2cc4076a |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-03-12T02:22:30Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-cdc558e2113346bc909ac8ac2cc4076a2023-09-06T04:51:16ZengElsevierIDCases2214-25092023-01-0133e01842Newly diagnosed AIDS patient with cerebellar JC virusSergio Alvarez-Mulett0Eli Sepkowitz1Douglas Sepkowitz2Department of Medicine, NYP-Brooklyn Methodist Hospital, Brooklyn, NY, USADepartment of Physical Medicine & Rehabilitation, Northwell Hospital, Manhasset, NY, USA; Correspondence to: Department of Physical Medicine & Rehabilitation, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA.Department of Infectious Disease, NYP-Brooklyn Methodist Hospital, Brooklyn, NY, USAWe present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability. Neuroimaging and CSF studies revealed a diagnosis of progressive multifocal leukoencephalopathy (PML). Although the patient’s human immunodeficiency virus (HIV) decreased considerably in response to anti-retroviral therapy, he continued to deteriorate clinically. Ultimately, the central nervous system (CNS) lesions, which were once centered in the cerebellum, became expansile throughout his posterior fossa. There are few reported cases of cerebellar PML in patients with AIDS.http://www.sciencedirect.com/science/article/pii/S221425092300166XJC virusCerebellumImmune reconstitution |
| spellingShingle | Sergio Alvarez-Mulett Eli Sepkowitz Douglas Sepkowitz Newly diagnosed AIDS patient with cerebellar JC virus IDCases JC virus Cerebellum Immune reconstitution |
| title | Newly diagnosed AIDS patient with cerebellar JC virus |
| title_full | Newly diagnosed AIDS patient with cerebellar JC virus |
| title_fullStr | Newly diagnosed AIDS patient with cerebellar JC virus |
| title_full_unstemmed | Newly diagnosed AIDS patient with cerebellar JC virus |
| title_short | Newly diagnosed AIDS patient with cerebellar JC virus |
| title_sort | newly diagnosed aids patient with cerebellar jc virus |
| topic | JC virus Cerebellum Immune reconstitution |
| url | http://www.sciencedirect.com/science/article/pii/S221425092300166X |
| work_keys_str_mv | AT sergioalvarezmulett newlydiagnosedaidspatientwithcerebellarjcvirus AT elisepkowitz newlydiagnosedaidspatientwithcerebellarjcvirus AT douglassepkowitz newlydiagnosedaidspatientwithcerebellarjcvirus |