Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Indonesia
2014-04-01
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| Series: | Journal of Dentistry Indonesia |
| Subjects: | |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/196 |
| _version_ | 1811251835466416128 |
|---|---|
| author | Sawitri D. Pertami Melkior Pancasiyanuar Sefy A. Irasari Markus B. Rahardjo Wasilah Wasilah |
| author_facet | Sawitri D. Pertami Melkior Pancasiyanuar Sefy A. Irasari Markus B. Rahardjo Wasilah Wasilah |
| author_sort | Sawitri D. Pertami |
| collection | DOAJ |
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Drug resistance to synthetic antifungal medication is becoming a problem in the treatment of oral candidiasis, especially in immunocompromised patients.Probiotic has been known for its health benefits. It <span style="mso-spacerun: yes;"> </span>produces lactic acid and bacteriocin that has antibacterial effect. Research focuses on antifungal effect of probiotic, escpecially for </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. <span style="mso-spacerun: yes;"> </span>albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">is still needed. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Objective: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">To determinethe inhibition effect of probiotic in the growth of </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. albicans</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Methods: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">Three <span style="mso-spacerun: yes;"> </span>concentrations of </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">Lactobacillus acidophilus</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">-containing probiotic (McFarland 6, 8, 10) were used to determine their inhibition effect on </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. <span style="mso-spacerun: yes;"> </span>albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">(McFarland 0.5) growing in trypticase yeast-extract cystine (TYC) agar. The inhibition effect of probiotic was determined by <span style="mso-spacerun: yes;"> </span>measuring the inhibition zone produced after 48 hours of culture. Difference in inhibition zone among experimental groups was analyzed using one-way ANOVA and LSD post-test. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Results: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">Probiotic with McFarland 10 had the highest inhibition effect against </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">and the difference to other experimental groups was statistically significant (</span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">p</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;"><0.05). </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Conclusion: </span></strong><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">L. acidophilus </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">probiotic has inhibition effect in the growth of </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. albicans</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">.</span></p><p class="MsoNormal" style="text-align: left; line-height: normal; mso-layout-grid-align: none; text-autospace: none;"><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">DOI: </span>10.14693/jdi.v20i3.196</p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" 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| first_indexed | 2024-04-12T16:25:58Z |
| format | Article |
| id | doaj.art-cdc564454bd244578ec0b21715964b7a |
| institution | Directory Open Access Journal |
| issn | 1693-9697 2355-4800 |
| language | English |
| last_indexed | 2024-04-12T16:25:58Z |
| publishDate | 2014-04-01 |
| publisher | Faculty of Dentistry, Universitas Indonesia |
| record_format | Article |
| series | Journal of Dentistry Indonesia |
| spelling | doaj.art-cdc564454bd244578ec0b21715964b7a2022-12-22T03:25:23ZengFaculty of Dentistry, Universitas IndonesiaJournal of Dentistry Indonesia1693-96972355-48002014-04-01203646710.14693/jdi.v20i3.196156Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicansSawitri D. Pertami0Melkior Pancasiyanuar1Sefy A. Irasari2Markus B. Rahardjo3Wasilah Wasilah4Undergraduate Program Faculty of Dentistry Institute of Health Science Bhakti Wiyata Kediri 64114Undergraduate Program Faculty of Dentistry Institute of Health Science Bhakti Wiyata Kediri 64114Undergraduate Program Faculty of Dentistry Institute of Health Science Bhakti Wiyata Kediri 64114Faculty of Dentistry Institute of Health Science Bhakti Wiyata Kediri 64114Faculty of Dentistry Institute of Health Science Bhakti Wiyata Kediri 64114<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowMarkup /> <w:DoNotShowComments /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>IN</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNormal" style="text-align: left; line-height: normal; mso-layout-grid-align: none; text-autospace: none;"><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">Candida albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">is the most common organism causing oral candidiasis. Drug resistance to synthetic antifungal medication is becoming a problem in the treatment of oral candidiasis, especially in immunocompromised patients.Probiotic has been known for its health benefits. It <span style="mso-spacerun: yes;"> </span>produces lactic acid and bacteriocin that has antibacterial effect. Research focuses on antifungal effect of probiotic, escpecially for </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. <span style="mso-spacerun: yes;"> </span>albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">is still needed. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Objective: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">To determinethe inhibition effect of probiotic in the growth of </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. albicans</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Methods: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">Three <span style="mso-spacerun: yes;"> </span>concentrations of </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">Lactobacillus acidophilus</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">-containing probiotic (McFarland 6, 8, 10) were used to determine their inhibition effect on </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. <span style="mso-spacerun: yes;"> </span>albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">(McFarland 0.5) growing in trypticase yeast-extract cystine (TYC) agar. The inhibition effect of probiotic was determined by <span style="mso-spacerun: yes;"> </span>measuring the inhibition zone produced after 48 hours of culture. Difference in inhibition zone among experimental groups was analyzed using one-way ANOVA and LSD post-test. </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Results: </span></strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">Probiotic with McFarland 10 had the highest inhibition effect against </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. albicans </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">and the difference to other experimental groups was statistically significant (</span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">p</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;"><0.05). </span><strong><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-BoldMT","serif"; mso-bidi-font-family: TimesNewRomanPS-BoldMT; mso-ansi-language: IN;">Conclusion: </span></strong><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">L. acidophilus </span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">probiotic has inhibition effect in the growth of </span><em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPS-ItalicMT","serif"; mso-bidi-font-family: TimesNewRomanPS-ItalicMT; mso-ansi-language: IN;">C. albicans</span></em><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">.</span></p><p class="MsoNormal" style="text-align: left; line-height: normal; mso-layout-grid-align: none; text-autospace: none;"><span style="font-size: 8.0pt; mso-bidi-font-size: 10.0pt; font-family: "TimesNewRomanPSMT","serif"; mso-bidi-font-family: TimesNewRomanPSMT; mso-ansi-language: IN;">DOI: </span>10.14693/jdi.v20i3.196</p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" 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<!--[endif] -->http://jdentistry.ui.ac.id/index.php/JDI/article/view/196Candida albicansinhibition concentrationLactobacillus acidophilusprobiotic |
| spellingShingle | Sawitri D. Pertami Melkior Pancasiyanuar Sefy A. Irasari Markus B. Rahardjo Wasilah Wasilah Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans Journal of Dentistry Indonesia Candida albicans inhibition concentration Lactobacillus acidophilus probiotic |
| title | Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans |
| title_full | Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans |
| title_fullStr | Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans |
| title_full_unstemmed | Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans |
| title_short | Lactobacillus acidophilus Probiotic Inhibits the Growth of Candida albicans |
| title_sort | lactobacillus acidophilus probiotic inhibits the growth of candida albicans |
| topic | Candida albicans inhibition concentration Lactobacillus acidophilus probiotic |
| url | http://jdentistry.ui.ac.id/index.php/JDI/article/view/196 |
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