CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP.
Background: Multiple myeloma is the second most common hematologic malignancy after lymphomas. Few studies have characterized significant and full variables at the time of diagnosis of multiple myeloma in Colombia, and there is no data evaluating patients for follow-up. Materials and Methods: ...
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Tehran University of Medical Sciences
2023-01-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
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| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1522 |
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| author | Carlos Atencia-Flórez Catalina Quintero-Valencia María Mondragón-Arismendy Andrés Cardona-Arias Carlos Regino-Agamez Julián Vélez-Urrego |
| author_facet | Carlos Atencia-Flórez Catalina Quintero-Valencia María Mondragón-Arismendy Andrés Cardona-Arias Carlos Regino-Agamez Julián Vélez-Urrego |
| author_sort | Carlos Atencia-Flórez |
| collection | DOAJ |
| description |
Background: Multiple myeloma is the second most common hematologic malignancy after lymphomas. Few studies have characterized significant and full variables at the time of diagnosis of multiple myeloma in Colombia, and there is no data evaluating patients for follow-up.
Materials and Methods: A retrospective cohort study is presented, describing the clinical, laboratory, cytometric, and cytogenetic characteristics of patients with a de novo diagnosis of multiple myeloma evaluated in a reference hematology laboratory attached to a highly complex hospital in Medellín, Colombia. We follow them until death as a main outcome.
Results: A total of 170 patients with a de novo diagnosis of multiple myeloma were collected from a database of 421 patients with different monoclonal gammopathies. Mainly, it was found that 50.8% of the patients were men; the median age was 62 years; 65.4% had secretion of the IgG kappa; half of the patients presented International Staging System (ISS) Stage III. The β2 macroglobulin >4 mg/L and creatinine >2 mg/dl were the main variables significantly associated with survival (Hazard Ratio (HR) 2.4 and 2, respectively). Eighty-five percent of patients presented with bone lytic lesion involvement and less than 3% with extramedullary involvement. Conventional Banding Karyotype (CBK) genetic risk assessment yield was poor, compared with although scarce data regarding Cytogenetic risk assessment based on Fluorescence in-situ Hybridization (FISH).
Conclusion: The clinical profile of the patients with a de novo diagnosis of multiple myeloma in our cohort is similar to that described in international studies. The diagnosis of multiple myeloma was documented at younger ages, with more advanced stages, anemia, and a high percentage of bone disease. ISS provides an excellent tool for prognosis purposes. Cytogenetic risk assessment based on FISH should be done for all MM patients from therapeutic implications. We need standardized protocols for bone marrow sample manipulation and processing in order to guarantee good correlation for plasma cells count methods.
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| first_indexed | 2024-03-12T05:12:01Z |
| format | Article |
| id | doaj.art-cdc7ba1f2db84a3695054c56c2dea3fc |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T05:12:01Z |
| publishDate | 2023-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-cdc7ba1f2db84a3695054c56c2dea3fc2023-09-03T08:33:16ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072023-01-0117110.18502/ijhoscr.v17i1.11711CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP.Carlos Atencia-Flórez0Catalina Quintero-Valencia1María Mondragón-Arismendy2Andrés Cardona-Arias3Carlos Regino-Agamez4Julián Vélez-Urrego5Department of Internal Medicine, University of Antioquia School of Medicine, Medellín, ColombiaLaboratorio Integrado de Medicina Especializada – LIME, Medellin (Antioquia), ColombiaLaboratorio Integrado de Medicina Especializada – LIME, Medellin (Antioquia), ColombiaUniversity of Antioquia School of Medicine, the SURA Healthcare Insurance Company, Medellin (Antioquia), ColombiaDepartment of Internal Medicine, University of Antioquia School of Medicine, Medellín, ColombiaSan Vicente Foundation University Hospital, Medellin (Antioquia), Colombia Background: Multiple myeloma is the second most common hematologic malignancy after lymphomas. Few studies have characterized significant and full variables at the time of diagnosis of multiple myeloma in Colombia, and there is no data evaluating patients for follow-up. Materials and Methods: A retrospective cohort study is presented, describing the clinical, laboratory, cytometric, and cytogenetic characteristics of patients with a de novo diagnosis of multiple myeloma evaluated in a reference hematology laboratory attached to a highly complex hospital in Medellín, Colombia. We follow them until death as a main outcome. Results: A total of 170 patients with a de novo diagnosis of multiple myeloma were collected from a database of 421 patients with different monoclonal gammopathies. Mainly, it was found that 50.8% of the patients were men; the median age was 62 years; 65.4% had secretion of the IgG kappa; half of the patients presented International Staging System (ISS) Stage III. The β2 macroglobulin >4 mg/L and creatinine >2 mg/dl were the main variables significantly associated with survival (Hazard Ratio (HR) 2.4 and 2, respectively). Eighty-five percent of patients presented with bone lytic lesion involvement and less than 3% with extramedullary involvement. Conventional Banding Karyotype (CBK) genetic risk assessment yield was poor, compared with although scarce data regarding Cytogenetic risk assessment based on Fluorescence in-situ Hybridization (FISH). Conclusion: The clinical profile of the patients with a de novo diagnosis of multiple myeloma in our cohort is similar to that described in international studies. The diagnosis of multiple myeloma was documented at younger ages, with more advanced stages, anemia, and a high percentage of bone disease. ISS provides an excellent tool for prognosis purposes. Cytogenetic risk assessment based on FISH should be done for all MM patients from therapeutic implications. We need standardized protocols for bone marrow sample manipulation and processing in order to guarantee good correlation for plasma cells count methods. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1522Multiple myeloma; Cohort study; Survival; Colombia |
| spellingShingle | Carlos Atencia-Flórez Catalina Quintero-Valencia María Mondragón-Arismendy Andrés Cardona-Arias Carlos Regino-Agamez Julián Vélez-Urrego CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP. International Journal of Hematology-Oncology and Stem Cell Research Multiple myeloma; Cohort study; Survival; Colombia |
| title | CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP. |
| title_full | CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP. |
| title_fullStr | CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP. |
| title_full_unstemmed | CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP. |
| title_short | CLINICAL, LABORATORY, CYTOMETRY AND CYTOGENETIC CHARACTERISTICS OF A COHORT OF PATIENTS DIAGNOSED FOR THE FIRST TIME WITH MULTIPLE MYELOMA IN A THIRD-LEVEL HOSPITAL IN MEDELLÍN, COLOMBIA, SURVIVAL FROM A 8 YEARS FOLLOW-UP. |
| title_sort | clinical laboratory cytometry and cytogenetic characteristics of a cohort of patients diagnosed for the first time with multiple myeloma in a third level hospital in medellin colombia survival from a 8 years follow up |
| topic | Multiple myeloma; Cohort study; Survival; Colombia |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1522 |
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