Infections in patients with chronic lymphocytic leukemia
Introduction: Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. Method and Results: However, once treat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923001086 |
| _version_ | 1797732888543756288 |
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| author | Mariana Guarana Marcio Nucci |
| author_facet | Mariana Guarana Marcio Nucci |
| author_sort | Mariana Guarana |
| collection | DOAJ |
| description | Introduction: Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. Method and Results: However, once treatment is initiated, the spectrum of pathogens causing infection broadens, depending on the treatment regimens. With disease progression, cumulative immunosuppression occurs as a consequence of multiple treatment lines and the risk of infection further increases. On the other hand, the use of targeted therapies in the treatment of CLL have brought new risks of infection, with an increased incidence of invasive fungal diseases, particularly aspergillosis, in patients receiving Bruton kinase inhibitors. Conclusion: In this article, we review the epidemiology of infection in patients with CLL, taking into account the treatment regimen, and briefly discuss the management of infection. |
| first_indexed | 2024-03-12T12:20:01Z |
| format | Article |
| id | doaj.art-cdc9378bdcbf4741895747b77cf04c3b |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-03-12T12:20:01Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-cdc9378bdcbf4741895747b77cf04c3b2023-08-30T05:54:34ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-07-01453387393Infections in patients with chronic lymphocytic leukemiaMariana Guarana0Marcio Nucci1Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilUniversidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Grupo Oncoclinicas, Rio de Janeiro, RJ, Brazil; Corresponding author at: Hospital Universitário Clementino Fraga Filho, Rua Prof. Rodolpho Paulo Rocco 255 Sala 4A 12 – 21941-913, Brazil.Introduction: Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. Method and Results: However, once treatment is initiated, the spectrum of pathogens causing infection broadens, depending on the treatment regimens. With disease progression, cumulative immunosuppression occurs as a consequence of multiple treatment lines and the risk of infection further increases. On the other hand, the use of targeted therapies in the treatment of CLL have brought new risks of infection, with an increased incidence of invasive fungal diseases, particularly aspergillosis, in patients receiving Bruton kinase inhibitors. Conclusion: In this article, we review the epidemiology of infection in patients with CLL, taking into account the treatment regimen, and briefly discuss the management of infection.http://www.sciencedirect.com/science/article/pii/S2531137923001086Chronic lymphocytic leukemiaLeukemiaChronic lymphoid leukemiaInfectionImmunity |
| spellingShingle | Mariana Guarana Marcio Nucci Infections in patients with chronic lymphocytic leukemia Hematology, Transfusion and Cell Therapy Chronic lymphocytic leukemia Leukemia Chronic lymphoid leukemia Infection Immunity |
| title | Infections in patients with chronic lymphocytic leukemia |
| title_full | Infections in patients with chronic lymphocytic leukemia |
| title_fullStr | Infections in patients with chronic lymphocytic leukemia |
| title_full_unstemmed | Infections in patients with chronic lymphocytic leukemia |
| title_short | Infections in patients with chronic lymphocytic leukemia |
| title_sort | infections in patients with chronic lymphocytic leukemia |
| topic | Chronic lymphocytic leukemia Leukemia Chronic lymphoid leukemia Infection Immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2531137923001086 |
| work_keys_str_mv | AT marianaguarana infectionsinpatientswithchroniclymphocyticleukemia AT marcionucci infectionsinpatientswithchroniclymphocyticleukemia |