Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis
Background: Thalassemia is one of the most common hereditary disorders and Beta-thalassemia major is its severe form. The present study is concerned with the analysis of liver function, thyroid function and estimation of critical serum ions as well as hematological characteristics in beta-thalassemi...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-04-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/375 |
| _version_ | 1827834208518668288 |
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| author | Md. Fazlul Karim Md Ismail AKM Mahbub Hasan Hossain Uddin Shekhar |
| author_facet | Md. Fazlul Karim Md Ismail AKM Mahbub Hasan Hossain Uddin Shekhar |
| author_sort | Md. Fazlul Karim |
| collection | DOAJ |
| description | Background: Thalassemia is one of the most common hereditary disorders and Beta-thalassemia major is its severe form. The present study is concerned with the analysis of liver function, thyroid function and estimation of critical serum ions as well as hematological characteristics in beta-thalassemia patients and controls.
Subjects and Methods: The study included 54 patients with beta-thalassemia major and 54 healthy individuals matched by sex and age. The activity of Alanine transaminase (ALT), Alkaline phosphatase(ALP) and Aspartate transaminase (AST) were assessed in order to evaluate the liver function. Serum content of iron (Fe), calcium (Ca), magnesium (Mg), sodium (Na) and potassium (K) were also estimated. Tri iodothyronine (T3), Thyroxin (T4) and Thyroid-stimulating hormone (TSH) levels were assessed in order to evaluate the thyroid function. Hemoglobin (Hb), ferritin, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration(MCHC), total iron binding capacity (TIBC) and creatinine level were also measured.
Results: Significantly higher ALT (P< 0.001), AST (P< 0.05), ALP (P< 0.001) activities and lower creatinine (P< 0.001) level in beta-thalassemia patients were found in comparison to healthy individuals. Lower serum level of calcium (P<0.05), magnesium (P<0.05) and higher level of iron (P>0.05), sodium (P>0.05), potassium (P>0.05) have been found in patients in comparison to healthy individuals. Hematological parameters like Hb (P< 0.001), ferritin (P<0.05), HCT (P< 0.001), MCV (P< 0.05) and MCH (P< 0.05) have been significantly reduced in patients except MCHC (P>0.05). No significant difference was observed in thyroid function between patients and control group.
Conclusions: Our study demonstrates that beta-thalassemia patients and controls have difference in liver function, thyroid function, serum contents of ions and hematological characteristics. |
| first_indexed | 2024-03-12T05:46:54Z |
| format | Article |
| id | doaj.art-cdc9f761081e4407a4d1988789850414 |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T05:46:54Z |
| publishDate | 2016-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-cdc9f761081e4407a4d19887898504142023-09-03T05:36:49ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072016-04-01101Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysisMd. Fazlul Karim0Md Ismail1AKM Mahbub Hasan2Hossain Uddin Shekhar3Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, BangladeshDepartment of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, BangladeshDepartment of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, BangladeshDepartment of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, BangladeshBackground: Thalassemia is one of the most common hereditary disorders and Beta-thalassemia major is its severe form. The present study is concerned with the analysis of liver function, thyroid function and estimation of critical serum ions as well as hematological characteristics in beta-thalassemia patients and controls. Subjects and Methods: The study included 54 patients with beta-thalassemia major and 54 healthy individuals matched by sex and age. The activity of Alanine transaminase (ALT), Alkaline phosphatase(ALP) and Aspartate transaminase (AST) were assessed in order to evaluate the liver function. Serum content of iron (Fe), calcium (Ca), magnesium (Mg), sodium (Na) and potassium (K) were also estimated. Tri iodothyronine (T3), Thyroxin (T4) and Thyroid-stimulating hormone (TSH) levels were assessed in order to evaluate the thyroid function. Hemoglobin (Hb), ferritin, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration(MCHC), total iron binding capacity (TIBC) and creatinine level were also measured. Results: Significantly higher ALT (P< 0.001), AST (P< 0.05), ALP (P< 0.001) activities and lower creatinine (P< 0.001) level in beta-thalassemia patients were found in comparison to healthy individuals. Lower serum level of calcium (P<0.05), magnesium (P<0.05) and higher level of iron (P>0.05), sodium (P>0.05), potassium (P>0.05) have been found in patients in comparison to healthy individuals. Hematological parameters like Hb (P< 0.001), ferritin (P<0.05), HCT (P< 0.001), MCV (P< 0.05) and MCH (P< 0.05) have been significantly reduced in patients except MCHC (P>0.05). No significant difference was observed in thyroid function between patients and control group. Conclusions: Our study demonstrates that beta-thalassemia patients and controls have difference in liver function, thyroid function, serum contents of ions and hematological characteristics.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/375Beta-thalassemia majorLiver functionThyroid functionHematological characteristics |
| spellingShingle | Md. Fazlul Karim Md Ismail AKM Mahbub Hasan Hossain Uddin Shekhar Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis International Journal of Hematology-Oncology and Stem Cell Research Beta-thalassemia major Liver function Thyroid function Hematological characteristics |
| title | Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis |
| title_full | Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis |
| title_fullStr | Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis |
| title_full_unstemmed | Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis |
| title_short | Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis |
| title_sort | hematological and biochemical status of beta thalassemia major patients in bangladesh a comparative analysis |
| topic | Beta-thalassemia major Liver function Thyroid function Hematological characteristics |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/375 |
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