Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Short Peptide-Based Drugs in Human Blood Plasma

Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Short Peptide-Based Drugs in Human Blood Plasma

A novel HPLC-ESI-MS/MS method for simultaneous gonadotropin-releasing hormone (GnRH) analogs and somatostatin analog quantitation was developed and validated. The developed method was successfully applied to pharmacokinetic studies. The sample preparation process included solid-phase extraction (SPE...

Full description

Bibliographic Details
Main Authors: Elizaveta N. Fisher, Evgeny S. Melnikov, Vladimir Gegeckori, Natalya V. Potoldykova, Dmitry V. Enikeev, Kirill A. Pavlenko, Snezana Agatonovic-Kustrin, David W. Morton, Galina V. Ramenskaya
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
LC-ESI-MS/MS
peptide drugs
GnRH analogs
somatostatin analogue
solid-phase extraction
Online Access:https://www.mdpi.com/1420-3049/27/22/7831

Similar Items

Similar Items