Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Short Peptide-Based Drugs in Human Blood Plasma
A novel HPLC-ESI-MS/MS method for simultaneous gonadotropin-releasing hormone (GnRH) analogs and somatostatin analog quantitation was developed and validated. The developed method was successfully applied to pharmacokinetic studies. The sample preparation process included solid-phase extraction (SPE...
Main Authors: | Elizaveta N. Fisher, Evgeny S. Melnikov, Vladimir Gegeckori, Natalya V. Potoldykova, Dmitry V. Enikeev, Kirill A. Pavlenko, Snezana Agatonovic-Kustrin, David W. Morton, Galina V. Ramenskaya |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-11-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/22/7831 |
Similar Items
-
Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine
by: Farrah L. Saleh, M.D., et al.
Published: (2023-06-01) -
GnRH Analogues as a Co-Treatment to Therapy in Women of Reproductive Age with Cancer and Fertility Preservation
by: Georgios Valsamakis, et al.
Published: (2022-02-01) -
Gonadotropin-Releasing Hormone Receptors in Prostate Cancer: Molecular Aspects and Biological Functions
by: Fabrizio Fontana, et al.
Published: (2020-12-01) -
Neurobiological study of fish brains gives insights into the nature of Gonadotropin-releasing hormone 1-3 neurons.
by: Tomomi eKarigo, et al.
Published: (2013-11-01) -
GnRH Induces ERK-Dependent Bleb Formation in Gonadotrope Cells, Involving Recruitment of Members of a GnRH Receptor-Associated Signalosome to the Blebs
by: Liat Rahamim-Ben Navi, et al.
Published: (2017-06-01)