Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
Pneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococ...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003&lng=en&tlng=en |
| _version_ | 1819082928841293824 |
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| author | Cristiana M.C. Nascimento-Carvalho Antônio A. Lopes Maria Daniela B.S. Gomes Morgana P. Magalhães Juliana R. Oliveira Ana Luisa Vilas-Boas Roberta Ferracuti Maria Cristina C. Brandileone Maria Luiza L.S. Guerra Noraney N. Alves Ledilce A. Athayde Renilza M. Caldas Maria Goreth M. A. Barberino Jussara Duarte Maria Angélica S. Brandão Heonir Rocha Yehuda Benguigui José Luis Di Fabio |
| author_facet | Cristiana M.C. Nascimento-Carvalho Antônio A. Lopes Maria Daniela B.S. Gomes Morgana P. Magalhães Juliana R. Oliveira Ana Luisa Vilas-Boas Roberta Ferracuti Maria Cristina C. Brandileone Maria Luiza L.S. Guerra Noraney N. Alves Ledilce A. Athayde Renilza M. Caldas Maria Goreth M. A. Barberino Jussara Duarte Maria Angélica S. Brandão Heonir Rocha Yehuda Benguigui José Luis Di Fabio |
| author_sort | Cristiana M.C. Nascimento-Carvalho |
| collection | DOAJ |
| description | Pneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococcal strains recovered from the blood of children with community-acquired pneumonia (CAP) and to assess the clinical findings of pneumococcal bacteremic patients with pneumonia. In a 26 month prospective study, blood cultures were obtained as often as possible from children (<16 years of age) diagnosed with CAP in two emergency rooms. Antimicrobial drug susceptibility tests and serotyping were performed when pneumococcus was identified. We studied 3,431 cases and cultured blood samples from 65.5% of those. Pneumococcus was recovered from 0.8% of the blood samples. The differences in age, somnolence, wheezing and hospitalization among children with and without pneumococcal bacteremia were statistically significant. Pneumococcal bacteremia was age-related (mean 1.63 ± 1.55; median 0.92) and associated with somnolence and hospitalization among children with CAP. One strain was recovered from pleural fluid. Penicillin resistance was detected in 21.0% (4/19) of the strains at an intermediate level, whereas 63.0% of the strains were resistant to trimethoprim-sulfamethoxazole. The most common serotypes were 14 and 6B, and these serotypes included the resistant strains. Eight of our 18 isolates from blood were of types included in the heptavalent conjugate pneumococcal vaccine, recently licensed in the USA. |
| first_indexed | 2024-12-21T20:24:28Z |
| format | Article |
| id | doaj.art-cdcb4313e7cf4863a6fd4bec814c8790 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-21T20:24:28Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-cdcb4313e7cf4863a6fd4bec814c87902022-12-21T18:51:25ZengElsevierBrazilian Journal of Infectious Diseases1678-439151132010.1590/S1413-86702001000100003S1413-86702001000100003Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcusCristiana M.C. Nascimento-Carvalho0Antônio A. Lopes1Maria Daniela B.S. Gomes2Morgana P. Magalhães3Juliana R. Oliveira4Ana Luisa Vilas-Boas5Roberta Ferracuti6Maria Cristina C. Brandileone7Maria Luiza L.S. Guerra8Noraney N. Alves9Ledilce A. Athayde10Renilza M. Caldas11Maria Goreth M. A. Barberino12Jussara Duarte13Maria Angélica S. Brandão14Heonir Rocha15Yehuda Benguigui16José Luis Di Fabio17Universidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaInstituto Adolfo LutzInstituto Adolfo LutzUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaHospital AliançaHospital AliançaHospital AliançaUniversidade Federal da BahiaPan American Health OrganizationPan American Health OrganizationPneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococcal strains recovered from the blood of children with community-acquired pneumonia (CAP) and to assess the clinical findings of pneumococcal bacteremic patients with pneumonia. In a 26 month prospective study, blood cultures were obtained as often as possible from children (<16 years of age) diagnosed with CAP in two emergency rooms. Antimicrobial drug susceptibility tests and serotyping were performed when pneumococcus was identified. We studied 3,431 cases and cultured blood samples from 65.5% of those. Pneumococcus was recovered from 0.8% of the blood samples. The differences in age, somnolence, wheezing and hospitalization among children with and without pneumococcal bacteremia were statistically significant. Pneumococcal bacteremia was age-related (mean 1.63 ± 1.55; median 0.92) and associated with somnolence and hospitalization among children with CAP. One strain was recovered from pleural fluid. Penicillin resistance was detected in 21.0% (4/19) of the strains at an intermediate level, whereas 63.0% of the strains were resistant to trimethoprim-sulfamethoxazole. The most common serotypes were 14 and 6B, and these serotypes included the resistant strains. Eight of our 18 isolates from blood were of types included in the heptavalent conjugate pneumococcal vaccine, recently licensed in the USA.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003&lng=en&tlng=enStreptococcus pneumoniaeantimicrobial resistanceserotypesblood culturecommunity-acquired pneumoniachildren |
| spellingShingle | Cristiana M.C. Nascimento-Carvalho Antônio A. Lopes Maria Daniela B.S. Gomes Morgana P. Magalhães Juliana R. Oliveira Ana Luisa Vilas-Boas Roberta Ferracuti Maria Cristina C. Brandileone Maria Luiza L.S. Guerra Noraney N. Alves Ledilce A. Athayde Renilza M. Caldas Maria Goreth M. A. Barberino Jussara Duarte Maria Angélica S. Brandão Heonir Rocha Yehuda Benguigui José Luis Di Fabio Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus Brazilian Journal of Infectious Diseases Streptococcus pneumoniae antimicrobial resistance serotypes blood culture community-acquired pneumonia children |
| title | Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus |
| title_full | Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus |
| title_fullStr | Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus |
| title_full_unstemmed | Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus |
| title_short | Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus |
| title_sort | community acquired pneumonia among pediatric outpatients in salvador northeast brazil with emphasis on the role of pneumococcus |
| topic | Streptococcus pneumoniae antimicrobial resistance serotypes blood culture community-acquired pneumonia children |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003&lng=en&tlng=en |
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