High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.

High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.

Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Dkk1 competes with Wnt for binding to LRP6; binding of Dkk1 inhibits canonical signaling through formation of a...

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Bibliographic Details
Main Authors:	Sanjay K Mishra, Lacey Funair, Alex Cressley, George K Gittes, R Cartland Burns
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3522622?pdf=render

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