SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice

SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice

IntroductionSirtuin 1 (SIRT1) is a key player in aging and metabolism and regulates bone mass and architecture. Sexual dimorphism in skeletal effects of SIRT1 has been reported, with an unfavorable phenotype primarily in female mice.MethodsTo investigate the mechanisms of gender differences in SIRT1...

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Bibliographic Details
Main Authors: Hanna Artsi, Einav Cohen-Kfir, Ron Shahar, Noga Kalish-Achrai, Natan Lishinsky, Rivka Dresner-Pollak
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Endocrinology
Subjects:
sirtuin1
estrogen receptor alpha
129/Sv mice
microCT
femur
vertebrae
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1032262/full

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