A Case of Drug-Induced Hepatitis due to Lenalidomide
Lenalidomide is a recent thalidomide analog used for the treatment of refractory multiple myeloma. The main toxicity of this drug consists in severe neutropenia and thrombocytopenia. Lenalidomide-associated liver injury is rare, manifesting itself as elevated liver enzymes and hyperbilirubinemia rev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-04-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/326935 |
| _version_ | 1819268507292925952 |
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| author | M.-C. Zanella L. Rubbia-Brandt E. Giostra Y. Chalandon A. Hadengue L. Spahr |
| author_facet | M.-C. Zanella L. Rubbia-Brandt E. Giostra Y. Chalandon A. Hadengue L. Spahr |
| author_sort | M.-C. Zanella |
| collection | DOAJ |
| description | Lenalidomide is a recent thalidomide analog used for the treatment of refractory multiple myeloma. The main toxicity of this drug consists in severe neutropenia and thrombocytopenia. Lenalidomide-associated liver injury is rare, manifesting itself as elevated liver enzymes and hyperbilirubinemia reversible upon weeks after drug withdrawal. We report here in detail the clinical course as well as the biological and histological alterations of an acute lenalidomide-induced liver injury. Findings on liver biopsy allowed us to discriminate acute inflammatory changes due to the drug and minor associated lesions of graft-versus-host disease in this patient with recurrent myeloma after allogeneic bone marrow transplantation. |
| first_indexed | 2024-12-23T21:34:10Z |
| format | Article |
| id | doaj.art-cdcd618a21e84f4b931cdab1025ebbda |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-23T21:34:10Z |
| publishDate | 2011-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-cdcd618a21e84f4b931cdab1025ebbda2022-12-21T17:30:22ZengKarger PublishersCase Reports in Gastroenterology1662-06312011-04-015121722210.1159/000326935326935A Case of Drug-Induced Hepatitis due to LenalidomideM.-C. ZanellaL. Rubbia-BrandtE. GiostraY. ChalandonA. HadengueL. SpahrLenalidomide is a recent thalidomide analog used for the treatment of refractory multiple myeloma. The main toxicity of this drug consists in severe neutropenia and thrombocytopenia. Lenalidomide-associated liver injury is rare, manifesting itself as elevated liver enzymes and hyperbilirubinemia reversible upon weeks after drug withdrawal. We report here in detail the clinical course as well as the biological and histological alterations of an acute lenalidomide-induced liver injury. Findings on liver biopsy allowed us to discriminate acute inflammatory changes due to the drug and minor associated lesions of graft-versus-host disease in this patient with recurrent myeloma after allogeneic bone marrow transplantation.http://www.karger.com/Article/FullText/326935Liver biopsyMultiple myelomaDrug-induced liver injuryLenalidomideTransaminases |
| spellingShingle | M.-C. Zanella L. Rubbia-Brandt E. Giostra Y. Chalandon A. Hadengue L. Spahr A Case of Drug-Induced Hepatitis due to Lenalidomide Case Reports in Gastroenterology Liver biopsy Multiple myeloma Drug-induced liver injury Lenalidomide Transaminases |
| title | A Case of Drug-Induced Hepatitis due to Lenalidomide |
| title_full | A Case of Drug-Induced Hepatitis due to Lenalidomide |
| title_fullStr | A Case of Drug-Induced Hepatitis due to Lenalidomide |
| title_full_unstemmed | A Case of Drug-Induced Hepatitis due to Lenalidomide |
| title_short | A Case of Drug-Induced Hepatitis due to Lenalidomide |
| title_sort | case of drug induced hepatitis due to lenalidomide |
| topic | Liver biopsy Multiple myeloma Drug-induced liver injury Lenalidomide Transaminases |
| url | http://www.karger.com/Article/FullText/326935 |
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