Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles
Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Biochemistry and Biophysics Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580817301656 |
| _version_ | 1811257464956387328 |
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| author | Rakesh M. Patil Nanasaheb D. Thorat Prajkta B. Shete Poonam A. Bedge Shambala Gavde Meghnad G. Joshi Syed A.M. Tofail Raghvendra A. Bohara |
| author_facet | Rakesh M. Patil Nanasaheb D. Thorat Prajkta B. Shete Poonam A. Bedge Shambala Gavde Meghnad G. Joshi Syed A.M. Tofail Raghvendra A. Bohara |
| author_sort | Rakesh M. Patil |
| collection | DOAJ |
| description | Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed. At the end the time dependent nature of toxicity and its ultimate faith inside the body is being discussed. Keywords: SPIONs, Toxicity, Cellular alteration, Biomedical applications |
| first_indexed | 2024-04-12T17:57:45Z |
| format | Article |
| id | doaj.art-cdd00e3e0ae040b3986d57f84d6dfb8b |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-04-12T17:57:45Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-cdd00e3e0ae040b3986d57f84d6dfb8b2022-12-22T03:22:17ZengElsevierBiochemistry and Biophysics Reports2405-58082018-03-01136372Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticlesRakesh M. Patil0Nanasaheb D. Thorat1Prajkta B. Shete2Poonam A. Bedge3Shambala Gavde4Meghnad G. Joshi5Syed A.M. Tofail6Raghvendra A. Bohara7Directorate of Forensic Science Laboratory, Govt. of Maharashtra Kalina, Mumbai, India; Centre for Interdisciplinary Research, D.Y.Patil University, Kolhapur, IndiaMaterial and Surface Science Institute, Bernal Institute, University of Limerick, IrelandCentre for Interdisciplinary Research, D.Y.Patil University, Kolhapur, IndiaDepartment of Stem Cells and Regenerative Medicine, D.Y.Patil University, Kolhapur, IndiaCentre for Interdisciplinary Research, D.Y.Patil University, Kolhapur, IndiaDepartment of Stem Cells and Regenerative Medicine, D.Y.Patil University, Kolhapur, IndiaMaterial and Surface Science Institute, Bernal Institute, University of Limerick, IrelandCentre for Interdisciplinary Research, D.Y.Patil University, Kolhapur, India; Department of Stem Cells and Regenerative Medicine, D.Y.Patil University, Kolhapur, India; Research and Innovations for Comprehensive Health (RICH), Cell D.Y.Patil University, Kolhapur, India; Correspondence to: D.Y.Patil University, Kolhapur, India.Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed. At the end the time dependent nature of toxicity and its ultimate faith inside the body is being discussed. Keywords: SPIONs, Toxicity, Cellular alteration, Biomedical applicationshttp://www.sciencedirect.com/science/article/pii/S2405580817301656 |
| spellingShingle | Rakesh M. Patil Nanasaheb D. Thorat Prajkta B. Shete Poonam A. Bedge Shambala Gavde Meghnad G. Joshi Syed A.M. Tofail Raghvendra A. Bohara Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles Biochemistry and Biophysics Reports |
| title | Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles |
| title_full | Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles |
| title_fullStr | Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles |
| title_full_unstemmed | Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles |
| title_short | Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles |
| title_sort | comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S2405580817301656 |
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