RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL
Objective: To determine the association between p53 expression and the probability of organ confinement in patients with prostate cancer in Sardjito Hospital, Yogyakarta. Material & method: Prostate specimens were obtained from patients with clinical stage T1-T2 prostatic adenocarcinoma in S...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IKATAN AHLI UROLOGI INDONESIA
2011-01-01
|
| Series: | Jurnal Urologi Indonesia |
| Online Access: | http://juri.urologi.or.id/juri/article/view/68 |
| _version_ | 1811244106478780416 |
|---|---|
| author | Indrawarman Soeroharjo H R Danarto |
| author_facet | Indrawarman Soeroharjo H R Danarto |
| author_sort | Indrawarman Soeroharjo |
| collection | DOAJ |
| description | Objective: To determine the association between p53 expression and the probability of organ confinement in patients with prostate cancer in Sardjito Hospital, Yogyakarta. Material & method: Prostate specimens were obtained from patients with clinical stage T1-T2 prostatic adenocarcinoma in Sardjito Hospital between January 2007 and December 2008. Samples were processed and immunohistochemically stained in the Department of Anatomical Pathology Gadjah Mada University. Probability of organ confinement was determined by updated Partin table 2007 from preoperative serum PSA level, Gleason Score, and clinical stage. Correlation between p53 expression and probability of organ confinement were statistically analyzed by Spearman correlation test. Results: There were 28 prostate cancer patients eligible for this study. Mean age was 65,19 ± 10,9 (28 - 81) years old. Mean preoperative PSA level were 107,13 ± 165,82 (0,20 734,20) ng/ml. Mean number of p53 expression was 97,47 ± 97,27 (5 - 396)/HPF. Significant correlation was found between p53 expression and probability of organ confinement (Spearman r = -
0,441; p = 0,019). Conclusion: p53 expression was negatively correlated with the level of organ confinement in patients with prostate cancer |
| first_indexed | 2024-04-12T14:20:06Z |
| format | Article |
| id | doaj.art-cdd29096da624b2f95cc46bb81e3924f |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-04-12T14:20:06Z |
| publishDate | 2011-01-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-cdd29096da624b2f95cc46bb81e3924f2022-12-22T03:29:37ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022011-01-0118110.32421/juri.v18i1.6868RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITALIndrawarman SoeroharjoH R DanartoObjective: To determine the association between p53 expression and the probability of organ confinement in patients with prostate cancer in Sardjito Hospital, Yogyakarta. Material & method: Prostate specimens were obtained from patients with clinical stage T1-T2 prostatic adenocarcinoma in Sardjito Hospital between January 2007 and December 2008. Samples were processed and immunohistochemically stained in the Department of Anatomical Pathology Gadjah Mada University. Probability of organ confinement was determined by updated Partin table 2007 from preoperative serum PSA level, Gleason Score, and clinical stage. Correlation between p53 expression and probability of organ confinement were statistically analyzed by Spearman correlation test. Results: There were 28 prostate cancer patients eligible for this study. Mean age was 65,19 ± 10,9 (28 - 81) years old. Mean preoperative PSA level were 107,13 ± 165,82 (0,20 734,20) ng/ml. Mean number of p53 expression was 97,47 ± 97,27 (5 - 396)/HPF. Significant correlation was found between p53 expression and probability of organ confinement (Spearman r = - 0,441; p = 0,019). Conclusion: p53 expression was negatively correlated with the level of organ confinement in patients with prostate cancerhttp://juri.urologi.or.id/juri/article/view/68 |
| spellingShingle | Indrawarman Soeroharjo H R Danarto RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL Jurnal Urologi Indonesia |
| title | RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL |
| title_full | RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL |
| title_fullStr | RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL |
| title_full_unstemmed | RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL |
| title_short | RELATIONSHIP BETWEEN P53 EXPRESSION AND PROBABILITY OF ORGAN CONFINEMENT IN PATIENTS WITH PROSTATE CANCER IN SARDJITO HOSPITAL |
| title_sort | relationship between p53 expression and probability of organ confinement in patients with prostate cancer in sardjito hospital |
| url | http://juri.urologi.or.id/juri/article/view/68 |
| work_keys_str_mv | AT indrawarmansoeroharjo relationshipbetweenp53expressionandprobabilityoforganconfinementinpatientswithprostatecancerinsardjitohospital AT hrdanarto relationshipbetweenp53expressionandprobabilityoforganconfinementinpatientswithprostatecancerinsardjitohospital |