Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India
PURPOSE: To evaluate the short-term efficacy and safety of 0.005% topical latanoprost in Indian eyes. DESIGN: Prospective non-randomised open-label multicentric trial. METHODS: One hundred and fifty patients with ocular hypertension (OHT), primary open-angle, pseudoexfoliation or pigment...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2005-03-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2005;volume=53;issue=1;spage=23;epage=30;aulast= |
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| author | Thomas Ravi Parikh Rajul Sood Devendra Vijaya L Chandra Sekhar G Sood Narendra Baskaran M Kalyani Prasad K |
| author_facet | Thomas Ravi Parikh Rajul Sood Devendra Vijaya L Chandra Sekhar G Sood Narendra Baskaran M Kalyani Prasad K |
| author_sort | Thomas Ravi |
| collection | DOAJ |
| description | PURPOSE: To evaluate the short-term efficacy and safety of 0.005% topical latanoprost in Indian eyes. DESIGN: Prospective non-randomised open-label multicentric trial. METHODS: One hundred and fifty patients with ocular hypertension (OHT), primary open-angle, pseudoexfoliation or pigmentary glaucoma were enrolled at four centers. Each center contributed at least 20 patients. Following baseline measurements, 0.005% latanoprost was applied topically once daily in the evening for three months. Patients were examined at 2, 6 and 12 weeks. The primary outcome measure was mean intraocular pressure (IOP) reduction. The mean diurnal variation of IOP (difference between highest and lowest IOP) at baseline and at 12-weeks was compared. RESULTS: One hundred and thirty of 150 enrolled patients completed the study. One randomly selected eye of each patient was included for analysis. At three months, latanoprost reduced the mean IOP from 24.9 (± 3.16) mmHg at baseline to 16.10 (± 2.7) mmHg, a reduction of 35.25%. 83% had a reduction in IOP of > 25%. The IOP reduction was maintained throughout the study period, and was not affected by gender or age of the patient. One eye did not show any response to the drug. Daytime diurnal variation of IOP was reduced from 4.5 to 2.9 mmHg. 20 patients had conjunctival hyperemia. Six patients had side effects requiring withdrawal from the study. CONCLUSIONS: In this short-term multicentric study, latanoprost effectively reduced IOP and stabilised the diurnal curve in Indian eyes. There were no clinically significant ocular or systemic adverse effects. |
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| format | Article |
| id | doaj.art-cdd3554f5b304880a2eb2d7605c1dc9d |
| institution | Directory Open Access Journal |
| issn | 0301-4738 |
| language | English |
| last_indexed | 2024-12-11T01:37:19Z |
| publishDate | 2005-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-cdd3554f5b304880a2eb2d7605c1dc9d2022-12-22T01:25:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47382005-03-015312330Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in IndiaThomas RaviParikh RajulSood DevendraVijaya LChandra Sekhar GSood NarendraBaskaran MKalyani Prasad KPURPOSE: To evaluate the short-term efficacy and safety of 0.005% topical latanoprost in Indian eyes. DESIGN: Prospective non-randomised open-label multicentric trial. METHODS: One hundred and fifty patients with ocular hypertension (OHT), primary open-angle, pseudoexfoliation or pigmentary glaucoma were enrolled at four centers. Each center contributed at least 20 patients. Following baseline measurements, 0.005% latanoprost was applied topically once daily in the evening for three months. Patients were examined at 2, 6 and 12 weeks. The primary outcome measure was mean intraocular pressure (IOP) reduction. The mean diurnal variation of IOP (difference between highest and lowest IOP) at baseline and at 12-weeks was compared. RESULTS: One hundred and thirty of 150 enrolled patients completed the study. One randomly selected eye of each patient was included for analysis. At three months, latanoprost reduced the mean IOP from 24.9 (± 3.16) mmHg at baseline to 16.10 (± 2.7) mmHg, a reduction of 35.25%. 83% had a reduction in IOP of > 25%. The IOP reduction was maintained throughout the study period, and was not affected by gender or age of the patient. One eye did not show any response to the drug. Daytime diurnal variation of IOP was reduced from 4.5 to 2.9 mmHg. 20 patients had conjunctival hyperemia. Six patients had side effects requiring withdrawal from the study. CONCLUSIONS: In this short-term multicentric study, latanoprost effectively reduced IOP and stabilised the diurnal curve in Indian eyes. There were no clinically significant ocular or systemic adverse effects.http://www.ijo.in/article.asp?issn=0301-4738;year=2005;volume=53;issue=1;spage=23;epage=30;aulast=LatanoprostsafetyefficacyglaucomaIndian eyes |
| spellingShingle | Thomas Ravi Parikh Rajul Sood Devendra Vijaya L Chandra Sekhar G Sood Narendra Baskaran M Kalyani Prasad K Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India Indian Journal of Ophthalmology Latanoprost safety efficacy glaucoma Indian eyes |
| title | Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India |
| title_full | Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India |
| title_fullStr | Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India |
| title_full_unstemmed | Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India |
| title_short | Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India |
| title_sort | efficacy and safety of latanoprost for glaucoma treatment a three month multicentric study in india |
| topic | Latanoprost safety efficacy glaucoma Indian eyes |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2005;volume=53;issue=1;spage=23;epage=30;aulast= |
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