Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan
Pelvic osteosarcoma has a poor prognosis compared to osteosarcomas in other locations, and the reasons for this remain unknown. Surgical resection of pelvic osteosarcoma is technically demanding and often results in dysfunction and complications. In this study, we investigated the reasons underlying...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3320 |
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| author | Satoshi Takenaka Hironari Tamiya Toru Wakamatsu Sho Nakai Yoshinori Imura Hidetatsu Outani Toshinari Yagi Akira Kawai |
| author_facet | Satoshi Takenaka Hironari Tamiya Toru Wakamatsu Sho Nakai Yoshinori Imura Hidetatsu Outani Toshinari Yagi Akira Kawai |
| author_sort | Satoshi Takenaka |
| collection | DOAJ |
| description | Pelvic osteosarcoma has a poor prognosis compared to osteosarcomas in other locations, and the reasons for this remain unknown. Surgical resection of pelvic osteosarcoma is technically demanding and often results in dysfunction and complications. In this study, we investigated the reasons underlying the poor prognosis of pelvic osteosarcoma by comparing it to femoral osteosarcoma using data from the Bone Tumor Registry in Japan. We used propensity score analysis to determine whether surgical resection of pelvic osteosarcoma improved its prognosis. We demonstrated that pelvic osteosarcoma had a poor prognosis because it occurred more often in the elderly, often had larger tumor size, and had metastasis at presentation more often in comparison to femoral osteosarcoma. These three factors were also associated with the non-surgical treatment of pelvic osteosarcoma, which also led to a poor outcome. The overall survival rate was only comparable in pelvic osteosarcoma and femoral osteosarcoma in cases treated with surgical resection. Propensity score analysis revealed that surgical treatment improved the prognosis of pelvic osteosarcoma. As such, we propose that surgical resection should be considered based on tumor stage and patient age in order to improve the prognosis of pelvic osteosarcoma. |
| first_indexed | 2024-03-10T09:53:14Z |
| format | Article |
| id | doaj.art-cdd36642c3bb460cb78f1fe6b2db3822 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:53:14Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cdd36642c3bb460cb78f1fe6b2db38222023-11-22T02:36:02ZengMDPI AGCancers2072-66942021-07-011313332010.3390/cancers13133320Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in JapanSatoshi Takenaka0Hironari Tamiya1Toru Wakamatsu2Sho Nakai3Yoshinori Imura4Hidetatsu Outani5Toshinari Yagi6Akira Kawai7Musculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka 541-8567, JapanMusculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka 541-8567, JapanMusculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka 541-8567, JapanMusculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanMusculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka 541-8567, JapanMusculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center, Tokyo 104-0045, JapanPelvic osteosarcoma has a poor prognosis compared to osteosarcomas in other locations, and the reasons for this remain unknown. Surgical resection of pelvic osteosarcoma is technically demanding and often results in dysfunction and complications. In this study, we investigated the reasons underlying the poor prognosis of pelvic osteosarcoma by comparing it to femoral osteosarcoma using data from the Bone Tumor Registry in Japan. We used propensity score analysis to determine whether surgical resection of pelvic osteosarcoma improved its prognosis. We demonstrated that pelvic osteosarcoma had a poor prognosis because it occurred more often in the elderly, often had larger tumor size, and had metastasis at presentation more often in comparison to femoral osteosarcoma. These three factors were also associated with the non-surgical treatment of pelvic osteosarcoma, which also led to a poor outcome. The overall survival rate was only comparable in pelvic osteosarcoma and femoral osteosarcoma in cases treated with surgical resection. Propensity score analysis revealed that surgical treatment improved the prognosis of pelvic osteosarcoma. As such, we propose that surgical resection should be considered based on tumor stage and patient age in order to improve the prognosis of pelvic osteosarcoma.https://www.mdpi.com/2072-6694/13/13/3320pelvic osteosarcomasurgical resectionprognosispropensity score |
| spellingShingle | Satoshi Takenaka Hironari Tamiya Toru Wakamatsu Sho Nakai Yoshinori Imura Hidetatsu Outani Toshinari Yagi Akira Kawai Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan Cancers pelvic osteosarcoma surgical resection prognosis propensity score |
| title | Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan |
| title_full | Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan |
| title_fullStr | Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan |
| title_full_unstemmed | Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan |
| title_short | Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan |
| title_sort | impact of surgical resection and reasons for poor prognosis of pelvic osteosarcoma based on the bone tumor registry in japan |
| topic | pelvic osteosarcoma surgical resection prognosis propensity score |
| url | https://www.mdpi.com/2072-6694/13/13/3320 |
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