Role of pattern recognition receptors in sensing Mycobacterium tuberculosis
Mycobacterium tuberculosis is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis. Host immune cells not only mount the protective action agains...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023078441 |
| _version_ | 1827780341339783168 |
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| author | S.M. Neamul Kabir Zihad Nazifa Sifat Mohammad Ashraful Islam A.S.M. Monjur-Al-Hossain K.M. Yasif Kayes Sikdar Md Moklesur Rahman Sarker Jamil A. Shilpi Shaikh Jamal Uddin |
| author_facet | S.M. Neamul Kabir Zihad Nazifa Sifat Mohammad Ashraful Islam A.S.M. Monjur-Al-Hossain K.M. Yasif Kayes Sikdar Md Moklesur Rahman Sarker Jamil A. Shilpi Shaikh Jamal Uddin |
| author_sort | S.M. Neamul Kabir Zihad |
| collection | DOAJ |
| description | Mycobacterium tuberculosis is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis. Host immune cells not only mount the protective action against this pathogen but also serve as the primary niche for growth. Thus, recognition of this pathogen by host immune cells and following signaling cascades are key dictators of the disease state. Immune cells, mainly belonging to myeloid cell lineage, recognize a wide variety of Mycobacterium tuberculosis ligands ranging from carbohydrate and lipids to proteins to nucleic acids by different membrane-bound and soluble pattern recognition receptors. Simultaneous interaction between different host receptors and pathogen ligands leads to immune-inflammatory response as well as contributes to virulence. This review summarizes the contribution of pattern recognition receptors of host immune cells in recognizing Mycobacterium tuberculosis and subsequent initiation of signaling pathways to provide the molecular insight of the specific Mtb ligands interacting with specific PRR, key adaptor molecules of the downstream signaling pathways and the resultant effector functions which will aid in identifying novel drug targets, and developing novel drugs and adjuvants. |
| first_indexed | 2024-03-11T15:03:10Z |
| format | Article |
| id | doaj.art-cdd40ec4970040958fe80e0cf2f8174f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T15:03:10Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-cdd40ec4970040958fe80e0cf2f8174f2023-10-30T06:06:51ZengElsevierHeliyon2405-84402023-10-01910e20636Role of pattern recognition receptors in sensing Mycobacterium tuberculosisS.M. Neamul Kabir Zihad0Nazifa Sifat1Mohammad Ashraful Islam2A.S.M. Monjur-Al-Hossain3K.M. Yasif Kayes Sikdar4Md Moklesur Rahman Sarker5Jamil A. Shilpi6Shaikh Jamal Uddin7Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh; Corresponding author. Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.Department of Pharmacy, ASA University of Bangladesh, Dhaka, 1207, BangladeshDepartment of Pharmacy, University of Asia Pacific, Dhaka, 1205, BangladeshDepartment of Pharmaceutical Technology, University of Dhaka, Dhaka, 1000, BangladeshDepartment of Pharmaceutical Technology, University of Dhaka, Dhaka, 1000, BangladeshDepartment of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh; Department of Pharmacy, Gono University, Nolam, Mirzanagar, Savar, Dhaka 1344, BangladeshPharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, BangladeshPharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh; Corresponding author. Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh.Mycobacterium tuberculosis is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis. Host immune cells not only mount the protective action against this pathogen but also serve as the primary niche for growth. Thus, recognition of this pathogen by host immune cells and following signaling cascades are key dictators of the disease state. Immune cells, mainly belonging to myeloid cell lineage, recognize a wide variety of Mycobacterium tuberculosis ligands ranging from carbohydrate and lipids to proteins to nucleic acids by different membrane-bound and soluble pattern recognition receptors. Simultaneous interaction between different host receptors and pathogen ligands leads to immune-inflammatory response as well as contributes to virulence. This review summarizes the contribution of pattern recognition receptors of host immune cells in recognizing Mycobacterium tuberculosis and subsequent initiation of signaling pathways to provide the molecular insight of the specific Mtb ligands interacting with specific PRR, key adaptor molecules of the downstream signaling pathways and the resultant effector functions which will aid in identifying novel drug targets, and developing novel drugs and adjuvants.http://www.sciencedirect.com/science/article/pii/S2405844023078441Mycobacterium tuberculosisPattern recognition receptorCytokinesPhagocytosisInflammasome |
| spellingShingle | S.M. Neamul Kabir Zihad Nazifa Sifat Mohammad Ashraful Islam A.S.M. Monjur-Al-Hossain K.M. Yasif Kayes Sikdar Md Moklesur Rahman Sarker Jamil A. Shilpi Shaikh Jamal Uddin Role of pattern recognition receptors in sensing Mycobacterium tuberculosis Heliyon Mycobacterium tuberculosis Pattern recognition receptor Cytokines Phagocytosis Inflammasome |
| title | Role of pattern recognition receptors in sensing Mycobacterium tuberculosis |
| title_full | Role of pattern recognition receptors in sensing Mycobacterium tuberculosis |
| title_fullStr | Role of pattern recognition receptors in sensing Mycobacterium tuberculosis |
| title_full_unstemmed | Role of pattern recognition receptors in sensing Mycobacterium tuberculosis |
| title_short | Role of pattern recognition receptors in sensing Mycobacterium tuberculosis |
| title_sort | role of pattern recognition receptors in sensing mycobacterium tuberculosis |
| topic | Mycobacterium tuberculosis Pattern recognition receptor Cytokines Phagocytosis Inflammasome |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023078441 |
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