Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients.
BACKGROUND:Patients with end-stage renal disease have very high mortality. In individuals on hemodialysis, cardiovascular deaths account for ~50% of all deaths in this population, mostly due to arrhythmia. To determine the causes of these arrhythmic deaths is essential in order to adopt preventive s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6051653?pdf=render |
| _version_ | 1818992860710567936 |
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| author | Monica Coll Carles Ferrer-Costa Sara Pich Catarina Allegue Emilio Rodrigo Gema Fernández-Fresnedo Paloma Barreda Jesus Mates Angel Luis Martinez de Francisco Israel Ortega Anna Iglesias Oscar Campuzano Eduardo Salas Manuel Arias Ramon Brugada |
| author_facet | Monica Coll Carles Ferrer-Costa Sara Pich Catarina Allegue Emilio Rodrigo Gema Fernández-Fresnedo Paloma Barreda Jesus Mates Angel Luis Martinez de Francisco Israel Ortega Anna Iglesias Oscar Campuzano Eduardo Salas Manuel Arias Ramon Brugada |
| author_sort | Monica Coll |
| collection | DOAJ |
| description | BACKGROUND:Patients with end-stage renal disease have very high mortality. In individuals on hemodialysis, cardiovascular deaths account for ~50% of all deaths in this population, mostly due to arrhythmia. To determine the causes of these arrhythmic deaths is essential in order to adopt preventive strategies. The main objective of this study was to investigate whether, the presence of QTc interval alterations, from electrolyte abnormalities or presence of rare genetic variants, could have a relationship with sudden arrhythmogenic deaths in end-stage renal disease patients. METHODS:We recorded the pre- and post-dialysis QTc interval in 111 patients undergoing hemodialysis. In 47 of them, we analyzed 24 SCD-related genes including the most prevalent genes associated with long QT syndrome using a custom resequencing panel. RESULTS:We found a positive although not significant association between the presence of long QTc and mortality in a subset of end-stage renal disease patients. In addition, in five patients with long QTc only after dialysis (21.7%) we detected rare potentially pathogenic genetic variants. Three out of these five carriers subsequently died suddenly. CONCLUSIONS:Genetic background may be determinant in the risk of sudden cardiac death in these patients. We recommend evaluating the QTc interval before and after hemodialysis, and performing a genetic analysis of individuals with long QTc after hemodialysis. |
| first_indexed | 2024-12-20T20:32:52Z |
| format | Article |
| id | doaj.art-cdd76455697a4eaa8755ddad27d0f7bd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T20:32:52Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cdd76455697a4eaa8755ddad27d0f7bd2022-12-21T19:27:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e020075610.1371/journal.pone.0200756Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients.Monica CollCarles Ferrer-CostaSara PichCatarina AllegueEmilio RodrigoGema Fernández-FresnedoPaloma BarredaJesus MatesAngel Luis Martinez de FranciscoIsrael OrtegaAnna IglesiasOscar CampuzanoEduardo SalasManuel AriasRamon BrugadaBACKGROUND:Patients with end-stage renal disease have very high mortality. In individuals on hemodialysis, cardiovascular deaths account for ~50% of all deaths in this population, mostly due to arrhythmia. To determine the causes of these arrhythmic deaths is essential in order to adopt preventive strategies. The main objective of this study was to investigate whether, the presence of QTc interval alterations, from electrolyte abnormalities or presence of rare genetic variants, could have a relationship with sudden arrhythmogenic deaths in end-stage renal disease patients. METHODS:We recorded the pre- and post-dialysis QTc interval in 111 patients undergoing hemodialysis. In 47 of them, we analyzed 24 SCD-related genes including the most prevalent genes associated with long QT syndrome using a custom resequencing panel. RESULTS:We found a positive although not significant association between the presence of long QTc and mortality in a subset of end-stage renal disease patients. In addition, in five patients with long QTc only after dialysis (21.7%) we detected rare potentially pathogenic genetic variants. Three out of these five carriers subsequently died suddenly. CONCLUSIONS:Genetic background may be determinant in the risk of sudden cardiac death in these patients. We recommend evaluating the QTc interval before and after hemodialysis, and performing a genetic analysis of individuals with long QTc after hemodialysis.http://europepmc.org/articles/PMC6051653?pdf=render |
| spellingShingle | Monica Coll Carles Ferrer-Costa Sara Pich Catarina Allegue Emilio Rodrigo Gema Fernández-Fresnedo Paloma Barreda Jesus Mates Angel Luis Martinez de Francisco Israel Ortega Anna Iglesias Oscar Campuzano Eduardo Salas Manuel Arias Ramon Brugada Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. PLoS ONE |
| title | Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. |
| title_full | Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. |
| title_fullStr | Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. |
| title_full_unstemmed | Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. |
| title_short | Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients. |
| title_sort | role of genetic and electrolyte abnormalities in prolonged qtc interval and sudden cardiac death in end stage renal disease patients |
| url | http://europepmc.org/articles/PMC6051653?pdf=render |
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