ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

Summary: The ATR kinase safeguards genomic integrity during S phase, but how ATR protects DNA replication forks remains incompletely understood. Here, we combine four distinct assays to analyze ATR functions at ongoing and newly assembled replication forks upon replication inhibition by hydroxyurea....

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Detalles Bibliográficos
Main Authors: Wendy Leung, Antoine Simoneau, Sneha Saxena, Jessica Jackson, Parasvi S. Patel, Mangsi Limbu, Alessandro Vindigni, Lee Zou
Formato: Artigo
Idioma:English
Publicado: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124723008033

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