Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis
Objective. To investigate sodium fluoride (Ossin, "Grunental") influence on bone mineral density and metabolism in pts with rheumatoid arthritis (RA). Material and methods. An 6-month open controlled investigation was carried out. 30 women were included in 2 groups: premenopausal (aged 20-...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2003-08-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1212 |
| _version_ | 1826556353418625024 |
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| author | E. A. Kupavtseva N G Klyukvina R M Balabanova T. V. Lebedeva A. V. Smirnov |
| author_facet | E. A. Kupavtseva N G Klyukvina R M Balabanova T. V. Lebedeva A. V. Smirnov |
| author_sort | E. A. Kupavtseva |
| collection | DOAJ |
| description | Objective. To investigate sodium fluoride (Ossin, "Grunental") influence on bone mineral density and metabolism in pts with rheumatoid arthritis (RA). Material and methods. An 6-month open controlled investigation was carried out. 30 women were included in 2 groups: premenopausal (aged 20-40 years) (PRM) and postmenopausal (aged 50-65 years) (PSM). 2 control groups were formed according to similar pairs method. Each contained 15 women of corresponding activity, disease duration and age. Pts received sodium fluoride 80 mg/day and Calcium Sandos 500 mg/day. Densitometry (QDR 1000 Hologic) and bone metabolism biochemical markers examination were performed at the beginning and at the end of the study. Bone phosphatase (BP) C- terminal propeptid of type I collagen (PICP), osteocalcin in serum, deoxypiridinolin and piridinolin in urine were measured with immunoenzyme assay ("METRA Biosystems”). Results. BP level increased during follow up in both PSM and PRM groups (from 22,9±I4,0 to 37,7+16,0, p<0,00l and from 20,7±8,9 to 26,7±12,6, p<0,05 respectively). There were no changes of other BM. 2,5% increase of lumbar BMD was detected in PRM group (p<0,05 - Fisher exact lest). Control group lumbar BMD decreased by 4,45%. Conclusion. Ossin significantly increased lumbar BMD in premenopausal RA pts. |
| first_indexed | 2024-04-09T22:29:58Z |
| format | Article |
| id | doaj.art-cdd80db0b1784f37b8ab5f65eac7188e |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2025-03-14T08:11:21Z |
| publishDate | 2003-08-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-cdd80db0b1784f37b8ab5f65eac7188e2025-03-02T13:23:25ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922003-08-01414535710.14412/1995-4484-2003-13341152Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritisE. A. KupavtsevaN G KlyukvinaR M BalabanovaT. V. LebedevaA. V. SmirnovObjective. To investigate sodium fluoride (Ossin, "Grunental") influence on bone mineral density and metabolism in pts with rheumatoid arthritis (RA). Material and methods. An 6-month open controlled investigation was carried out. 30 women were included in 2 groups: premenopausal (aged 20-40 years) (PRM) and postmenopausal (aged 50-65 years) (PSM). 2 control groups were formed according to similar pairs method. Each contained 15 women of corresponding activity, disease duration and age. Pts received sodium fluoride 80 mg/day and Calcium Sandos 500 mg/day. Densitometry (QDR 1000 Hologic) and bone metabolism biochemical markers examination were performed at the beginning and at the end of the study. Bone phosphatase (BP) C- terminal propeptid of type I collagen (PICP), osteocalcin in serum, deoxypiridinolin and piridinolin in urine were measured with immunoenzyme assay ("METRA Biosystems”). Results. BP level increased during follow up in both PSM and PRM groups (from 22,9±I4,0 to 37,7+16,0, p<0,00l and from 20,7±8,9 to 26,7±12,6, p<0,05 respectively). There were no changes of other BM. 2,5% increase of lumbar BMD was detected in PRM group (p<0,05 - Fisher exact lest). Control group lumbar BMD decreased by 4,45%. Conclusion. Ossin significantly increased lumbar BMD in premenopausal RA pts.https://rsp.mediar-press.net/rsp/article/view/1212ossinbone mineral densitybone phosphataserheumatoid arthritis |
| spellingShingle | E. A. Kupavtseva N G Klyukvina R M Balabanova T. V. Lebedeva A. V. Smirnov Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis Научно-практическая ревматология ossin bone mineral density bone phosphatase rheumatoid arthritis |
| title | Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis |
| title_full | Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis |
| title_fullStr | Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis |
| title_full_unstemmed | Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis |
| title_short | Changes of metabolism and mineral density of bone tissue during 6-months therapy with ossin in patients with rheumatoid arthritis |
| title_sort | changes of metabolism and mineral density of bone tissue during 6 months therapy with ossin in patients with rheumatoid arthritis |
| topic | ossin bone mineral density bone phosphatase rheumatoid arthritis |
| url | https://rsp.mediar-press.net/rsp/article/view/1212 |
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