Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity
Introduction: Quantitative electroencephalography (QEEG) brain frequency and network analyses are known to differentiate between disease stages in Parkinson's disease (PD) and are possible biomarkers. They correlate with cognitive decline. Little is known about changes in brain networks in rela...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00262/full |
| _version_ | 1811209992127119360 |
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| author | Florian Hatz Antonia Meyer Ronan Zimmermann Ute Gschwandtner Peter Fuhr |
| author_facet | Florian Hatz Antonia Meyer Ronan Zimmermann Ute Gschwandtner Peter Fuhr |
| author_sort | Florian Hatz |
| collection | DOAJ |
| description | Introduction: Quantitative electroencephalography (QEEG) brain frequency and network analyses are known to differentiate between disease stages in Parkinson's disease (PD) and are possible biomarkers. They correlate with cognitive decline. Little is known about changes in brain networks in relation to apathy.Objective/Aims: To analyze changes in brain network connectivities related to apathy.Methods: 40 PD patients (14 PD with mild cognitive deficits and 26 PD with normal cognition) were included. All patients had extensive neuropsychological testing; apathy was evaluated using the apathy evaluation score (AES, median 24.5, range 18–39). Resting state EEG was recorded with 256 electrodes and analyzed using fully automated Matlab® code (TAPEEG). For estimation of the connectivities between brain regions, PLI (phase lag index) was used, enhanced by a microstates segmentation.Results: After correction for multiple comparisons, significant correlations were found for single alpha2-band connectivities with the AES (p-values < 0.05). Lower connectivities, mainly involving the left fronto-polar region, were related to higher apathy scores.Conclusions: In our sample of patients with PD, apathy correlates with a network alteration mainly involving the left fronto-polar region. This might be due to dysfunction of the cortico-basal loop, modulating motivation. |
| first_indexed | 2024-04-12T04:48:29Z |
| format | Article |
| id | doaj.art-cdd8af5f949a45198d88300581a7c79f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T04:48:29Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-cdd8af5f949a45198d88300581a7c79f2022-12-22T03:47:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-08-01910.3389/fnagi.2017.00262238246Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic ConnectivityFlorian HatzAntonia MeyerRonan ZimmermannUte GschwandtnerPeter FuhrIntroduction: Quantitative electroencephalography (QEEG) brain frequency and network analyses are known to differentiate between disease stages in Parkinson's disease (PD) and are possible biomarkers. They correlate with cognitive decline. Little is known about changes in brain networks in relation to apathy.Objective/Aims: To analyze changes in brain network connectivities related to apathy.Methods: 40 PD patients (14 PD with mild cognitive deficits and 26 PD with normal cognition) were included. All patients had extensive neuropsychological testing; apathy was evaluated using the apathy evaluation score (AES, median 24.5, range 18–39). Resting state EEG was recorded with 256 electrodes and analyzed using fully automated Matlab® code (TAPEEG). For estimation of the connectivities between brain regions, PLI (phase lag index) was used, enhanced by a microstates segmentation.Results: After correction for multiple comparisons, significant correlations were found for single alpha2-band connectivities with the AES (p-values < 0.05). Lower connectivities, mainly involving the left fronto-polar region, were related to higher apathy scores.Conclusions: In our sample of patients with PD, apathy correlates with a network alteration mainly involving the left fronto-polar region. This might be due to dysfunction of the cortico-basal loop, modulating motivation.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00262/fullParkinson's diseaseapathyexecutive functionsquantitative electroencephalographyneuropsychology |
| spellingShingle | Florian Hatz Antonia Meyer Ronan Zimmermann Ute Gschwandtner Peter Fuhr Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity Frontiers in Aging Neuroscience Parkinson's disease apathy executive functions quantitative electroencephalography neuropsychology |
| title | Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity |
| title_full | Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity |
| title_fullStr | Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity |
| title_full_unstemmed | Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity |
| title_short | Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity |
| title_sort | apathy in patients with parkinson s disease correlates with alteration of left fronto polar electroencephalographic connectivity |
| topic | Parkinson's disease apathy executive functions quantitative electroencephalography neuropsychology |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00262/full |
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