Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity
Purpose: The aim of this study was to report the treatment outcomes of early and deferred laser in infants of aggressive posterior retinopathy of prematurity (APROP) after initial treatment with intravitreal Ranibizumab (IVR). Methods: In a prospective, randomized, interventional study, infants with...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=8;spage=2171;epage=2176;aulast=Gangwe |
| _version_ | 1818891131899871232 |
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| author | Anil Babanrao Gangwe Deepshikha Agrawal Aashish Kumar Gangrade Swapnil Madhukar Parchand Deepanshu Agrawal Raj Vardhan Azad |
| author_facet | Anil Babanrao Gangwe Deepshikha Agrawal Aashish Kumar Gangrade Swapnil Madhukar Parchand Deepanshu Agrawal Raj Vardhan Azad |
| author_sort | Anil Babanrao Gangwe |
| collection | DOAJ |
| description | Purpose: The aim of this study was to report the treatment outcomes of early and deferred laser in infants of aggressive posterior retinopathy of prematurity (APROP) after initial treatment with intravitreal Ranibizumab (IVR). Methods: In a prospective, randomized, interventional study, infants with APROP received IVR (0.25 mg) and were randomized into two groups prior to laser. Laser was done at 1 week (group 1) or at 6 weeks or earlier if there was a recurrence of plus disease (group 2). The structural outcome, number of laser spots, duration of laser procedure and refractive error at 6 months were compared. Favorable structural outcome was defined as, complete regression of disease at 6 weeks after laser. Results: 63 eyes of 32 infants with APROP were enrolled. Mean gestational age (GA) and birth weight (BW) were 30.2 ± 2.3 weeks and 1294 ± 372.8 grams respectively. GA, BW, and disease severity were comparable at baseline. 27 (90%) eyes in group 1 and 29 (93.5%) eyes in group 2 had favorable structural outcome (P = 0.61) at 6 weeks after laser. Eyes in group 2 (2149.8 ± 688.7) required lesser number of laser spots than group 1 (2570.8 ± 615) (P = 0.01). At six months, more eyes in group 1 had myopic refractive error (Mean spherical equivalent: –1.0D ± 1.3) than those in group 2 (Mean spherical equivalent: 0.5D ± 1.9) (P = 0.002). Conclusion: Infants with APROP receiving IVR have comparable structural outcomes after an early or deferred laser. Moreover, eyes undergoing deferred laser require less number of laser spots and have a less myopia at 6 months after laser. |
| first_indexed | 2024-12-19T17:35:56Z |
| format | Article |
| id | doaj.art-cddab0a3eee146999dd55bceb50d9892 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-19T17:35:56Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-cddab0a3eee146999dd55bceb50d98922022-12-21T20:12:20ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892021-01-016982171217610.4103/ijo.IJO_3016_20Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurityAnil Babanrao GangweDeepshikha AgrawalAashish Kumar GangradeSwapnil Madhukar ParchandDeepanshu AgrawalRaj Vardhan AzadPurpose: The aim of this study was to report the treatment outcomes of early and deferred laser in infants of aggressive posterior retinopathy of prematurity (APROP) after initial treatment with intravitreal Ranibizumab (IVR). Methods: In a prospective, randomized, interventional study, infants with APROP received IVR (0.25 mg) and were randomized into two groups prior to laser. Laser was done at 1 week (group 1) or at 6 weeks or earlier if there was a recurrence of plus disease (group 2). The structural outcome, number of laser spots, duration of laser procedure and refractive error at 6 months were compared. Favorable structural outcome was defined as, complete regression of disease at 6 weeks after laser. Results: 63 eyes of 32 infants with APROP were enrolled. Mean gestational age (GA) and birth weight (BW) were 30.2 ± 2.3 weeks and 1294 ± 372.8 grams respectively. GA, BW, and disease severity were comparable at baseline. 27 (90%) eyes in group 1 and 29 (93.5%) eyes in group 2 had favorable structural outcome (P = 0.61) at 6 weeks after laser. Eyes in group 2 (2149.8 ± 688.7) required lesser number of laser spots than group 1 (2570.8 ± 615) (P = 0.01). At six months, more eyes in group 1 had myopic refractive error (Mean spherical equivalent: –1.0D ± 1.3) than those in group 2 (Mean spherical equivalent: 0.5D ± 1.9) (P = 0.002). Conclusion: Infants with APROP receiving IVR have comparable structural outcomes after an early or deferred laser. Moreover, eyes undergoing deferred laser require less number of laser spots and have a less myopia at 6 months after laser.http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=8;spage=2171;epage=2176;aulast=Gangweaggressive posterior retinopathy of prematurityanti-vegflaser ablationranibizumabretinopathy of prematurity/rop |
| spellingShingle | Anil Babanrao Gangwe Deepshikha Agrawal Aashish Kumar Gangrade Swapnil Madhukar Parchand Deepanshu Agrawal Raj Vardhan Azad Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity Indian Journal of Ophthalmology aggressive posterior retinopathy of prematurity anti-vegf laser ablation ranibizumab retinopathy of prematurity/rop |
| title | Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity |
| title_full | Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity |
| title_fullStr | Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity |
| title_full_unstemmed | Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity |
| title_short | Outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity |
| title_sort | outcomes of early versus deferred laser after intravitreal ranibizumab in aggressive posterior retinopathy of prematurity |
| topic | aggressive posterior retinopathy of prematurity anti-vegf laser ablation ranibizumab retinopathy of prematurity/rop |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=8;spage=2171;epage=2176;aulast=Gangwe |
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