Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension
Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output and subsequently elevated pulmonary arterial pr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2014;volume=9;issue=5;spage=42;epage=46;aulast=Saleemi |
| _version_ | 1819110128989765632 |
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| author | Sarfraz Saleemi Majdy M. Idrees |
| author_facet | Sarfraz Saleemi Majdy M. Idrees |
| author_sort | Sarfraz Saleemi |
| collection | DOAJ |
| description | Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output and subsequently elevated pulmonary arterial pressures (PAP). However, patients with POPH develop a progressive increase in pulmonary vascular resistance (PVR), which is generally lower than that observed in other forms of PAH.
The prognosis of untreated patients with POPH is very poor and the outcome of liver transplant (LT) in those patients is determined by the degree of severity of the associated pulmonary hemodynamics.
In this narrative review, we describe the clinical presentation of POPH, the pathobiology, and the clinical implication of pulmonary hemodynamics. We also provide evidence-based recommendations for the diagnosic and management approaches of POPH. |
| first_indexed | 2024-12-22T03:36:48Z |
| format | Article |
| id | doaj.art-cddb0985745e4a59becdf824d7a87e5b |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-12-22T03:36:48Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-cddb0985745e4a59becdf824d7a87e5b2022-12-21T18:40:22ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572014-01-0195424610.4103/1817-1737.134021Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertensionSarfraz SaleemiMajdy M. IdreesPortopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output and subsequently elevated pulmonary arterial pressures (PAP). However, patients with POPH develop a progressive increase in pulmonary vascular resistance (PVR), which is generally lower than that observed in other forms of PAH. The prognosis of untreated patients with POPH is very poor and the outcome of liver transplant (LT) in those patients is determined by the degree of severity of the associated pulmonary hemodynamics. In this narrative review, we describe the clinical presentation of POPH, the pathobiology, and the clinical implication of pulmonary hemodynamics. We also provide evidence-based recommendations for the diagnosic and management approaches of POPH.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2014;volume=9;issue=5;spage=42;epage=46;aulast=SaleemiLiver transplantportal hypertensionportopulmonary hypertensionpulmonary arterial hypertensionvasodilator therapySaudi Association for Pulmonary Hypertension Guidelines |
| spellingShingle | Sarfraz Saleemi Majdy M. Idrees Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension Annals of Thoracic Medicine Liver transplant portal hypertension portopulmonary hypertension pulmonary arterial hypertension vasodilator therapy Saudi Association for Pulmonary Hypertension Guidelines |
| title | Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension |
| title_full | Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension |
| title_fullStr | Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension |
| title_full_unstemmed | Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension |
| title_short | Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension |
| title_sort | saudi guidelines on the diagnosis and treatment of pulmonary hypertension portopulmonary hypertension |
| topic | Liver transplant portal hypertension portopulmonary hypertension pulmonary arterial hypertension vasodilator therapy Saudi Association for Pulmonary Hypertension Guidelines |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2014;volume=9;issue=5;spage=42;epage=46;aulast=Saleemi |
| work_keys_str_mv | AT sarfrazsaleemi saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionportopulmonaryhypertension AT majdymidrees saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionportopulmonaryhypertension |