Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research
We present a set of data on human and chicken Toxoplasma gondiiseroprevalence that was investigated and analysed in light of groundwater vulnerability information in an area endemic for waterborne toxoplasmosis in Brazil. Hydrogeological assessment was undertaken to select sites for water collection...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2015-11-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000700929&lng=en&tlng=en |
| _version_ | 1827879817420210176 |
|---|---|
| author | Flávia Pereira Vieira Maria da Glória Alves Livia Mattos Martins Alba Lucínia Peixoto Rangel Jitender Prakash Dubey Dolores Hill Lilian Maria Garcia Bahia-Oliveira/ |
| author_facet | Flávia Pereira Vieira Maria da Glória Alves Livia Mattos Martins Alba Lucínia Peixoto Rangel Jitender Prakash Dubey Dolores Hill Lilian Maria Garcia Bahia-Oliveira/ |
| author_sort | Flávia Pereira Vieira |
| collection | DOAJ |
| description | We present a set of data on human and chicken Toxoplasma gondiiseroprevalence that was investigated and analysed in light of groundwater vulnerability information in an area endemic for waterborne toxoplasmosis in Brazil. Hydrogeological assessment was undertaken to select sites for water collection from wells for T. gondiioocyst testing and for collecting blood from free-range chickens and humans for anti-T. gondiiserologic testing. Serologic testing of human specimens was done using conventional commercial tests and a sporozoite-specific embryogenesis-related protein (TgERP), which is able to differentiate whether infection resulted from tissue cysts or oocysts. Water specimens were negative for the presence of viable T. gondiioocysts. However, seroprevalence in free-range chickens was significantly associated with vulnerability of groundwater to surface contamination (p < 0.0001; odds ratio: 4.73, 95% confidence interval: 2.18-10.2). Surprisingly, a high prevalence of antibodies against TgERP was detected in human specimens, suggesting the possibility of a continuous contamination of drinking water with T. gondiioocysts in this endemic setting. These findings and the new proposed approach to investigate and analyse endemic toxoplasmosis in light of groundwater vulnerability information associated with prevalence in humans estimated by oocyst antigens recognition have implications for the potential role of hydrogeological assessment in researching waterborne toxoplasmosis at a global scale. |
| first_indexed | 2024-03-12T18:11:42Z |
| format | Article |
| id | doaj.art-cddc16c1ee044e3c8cdf0d1dcc18764a |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:11:42Z |
| publishDate | 2015-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-cddc16c1ee044e3c8cdf0d1dcc18764a2023-08-02T09:15:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602015-11-01110792993510.1590/0074-02760150262S0074-02762015000700929Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further researchFlávia Pereira VieiraMaria da Glória AlvesLivia Mattos MartinsAlba Lucínia Peixoto RangelJitender Prakash DubeyDolores HillLilian Maria Garcia Bahia-Oliveira/We present a set of data on human and chicken Toxoplasma gondiiseroprevalence that was investigated and analysed in light of groundwater vulnerability information in an area endemic for waterborne toxoplasmosis in Brazil. Hydrogeological assessment was undertaken to select sites for water collection from wells for T. gondiioocyst testing and for collecting blood from free-range chickens and humans for anti-T. gondiiserologic testing. Serologic testing of human specimens was done using conventional commercial tests and a sporozoite-specific embryogenesis-related protein (TgERP), which is able to differentiate whether infection resulted from tissue cysts or oocysts. Water specimens were negative for the presence of viable T. gondiioocysts. However, seroprevalence in free-range chickens was significantly associated with vulnerability of groundwater to surface contamination (p < 0.0001; odds ratio: 4.73, 95% confidence interval: 2.18-10.2). Surprisingly, a high prevalence of antibodies against TgERP was detected in human specimens, suggesting the possibility of a continuous contamination of drinking water with T. gondiioocysts in this endemic setting. These findings and the new proposed approach to investigate and analyse endemic toxoplasmosis in light of groundwater vulnerability information associated with prevalence in humans estimated by oocyst antigens recognition have implications for the potential role of hydrogeological assessment in researching waterborne toxoplasmosis at a global scale.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000700929&lng=en&tlng=enToxoplasma gondiigroundwater contaminationoocystshydrogeologyTgERPgeomedicine |
| spellingShingle | Flávia Pereira Vieira Maria da Glória Alves Livia Mattos Martins Alba Lucínia Peixoto Rangel Jitender Prakash Dubey Dolores Hill Lilian Maria Garcia Bahia-Oliveira/ Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research Memorias do Instituto Oswaldo Cruz Toxoplasma gondii groundwater contamination oocysts hydrogeology TgERP geomedicine |
| title | Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research |
| title_full | Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research |
| title_fullStr | Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research |
| title_full_unstemmed | Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research |
| title_short | Waterborne toxoplasmosis investigated and analysed under hydrogeological assessment: new data and perspectives for further research |
| title_sort | waterborne toxoplasmosis investigated and analysed under hydrogeological assessment new data and perspectives for further research |
| topic | Toxoplasma gondii groundwater contamination oocysts hydrogeology TgERP geomedicine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000700929&lng=en&tlng=en |
| work_keys_str_mv | AT flaviapereiravieira waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch AT mariadagloriaalves waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch AT liviamattosmartins waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch AT albaluciniapeixotorangel waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch AT jitenderprakashdubey waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch AT doloreshill waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch AT lilianmariagarciabahiaoliveira waterbornetoxoplasmosisinvestigatedandanalysedunderhydrogeologicalassessmentnewdataandperspectivesforfurtherresearch |