The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects
It is well known that the enzyme catalyzes the first step of branched-chain amino acid (BCAA) catabolism is branched-chain amino transferase (BCAT), which is involved in the synthesis and degradation of leucine, isoleucine and valine. There are two main subtypes of human branched chain amino transfe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.988290/full |
| _version_ | 1811278318140391424 |
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| author | Xiazhen Nong Xiazhen Nong Caiyun Zhang Junmin Wang Peilun Ding Guang Ji Tao Wu |
| author_facet | Xiazhen Nong Xiazhen Nong Caiyun Zhang Junmin Wang Peilun Ding Guang Ji Tao Wu |
| author_sort | Xiazhen Nong |
| collection | DOAJ |
| description | It is well known that the enzyme catalyzes the first step of branched-chain amino acid (BCAA) catabolism is branched-chain amino transferase (BCAT), which is involved in the synthesis and degradation of leucine, isoleucine and valine. There are two main subtypes of human branched chain amino transferase (hBCAT), including cytoplasmic BCAT (BCAT1) and mitochondrial BCAT (BCAT2). In recent years, the role of BCAT in tumors has attracted the attention of scientists, and there have been continuous research reports that BCAT plays a role in the tumor, Alzheimer’s disease, myeloid leukaemia and other diseases. It plays a significant role in the growth and development of diseases, and new discoveries about this gene in some diseases are made every year. BCAT usually promotes cancer proliferation and invasion by activating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway and activating Wnt/β-catenin signal transduction. This article reviews the role and mechanism of BCAT in different diseases, as well as the recent biomedical research progress. This review aims to make a comprehensive summary of the role and mechanism of BCAT in different diseases and to provide new research ideas for the treatment, prognosis and prevention of certain diseases. |
| first_indexed | 2024-04-13T00:32:42Z |
| format | Article |
| id | doaj.art-cdddefc610b04cfcb758e640817ae2b6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T00:32:42Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-cdddefc610b04cfcb758e640817ae2b62022-12-22T03:10:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.988290988290The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospectsXiazhen Nong0Xiazhen Nong1Caiyun Zhang2Junmin Wang3Peilun Ding4Guang Ji5Tao Wu6Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaIt is well known that the enzyme catalyzes the first step of branched-chain amino acid (BCAA) catabolism is branched-chain amino transferase (BCAT), which is involved in the synthesis and degradation of leucine, isoleucine and valine. There are two main subtypes of human branched chain amino transferase (hBCAT), including cytoplasmic BCAT (BCAT1) and mitochondrial BCAT (BCAT2). In recent years, the role of BCAT in tumors has attracted the attention of scientists, and there have been continuous research reports that BCAT plays a role in the tumor, Alzheimer’s disease, myeloid leukaemia and other diseases. It plays a significant role in the growth and development of diseases, and new discoveries about this gene in some diseases are made every year. BCAT usually promotes cancer proliferation and invasion by activating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway and activating Wnt/β-catenin signal transduction. This article reviews the role and mechanism of BCAT in different diseases, as well as the recent biomedical research progress. This review aims to make a comprehensive summary of the role and mechanism of BCAT in different diseases and to provide new research ideas for the treatment, prognosis and prevention of certain diseases.https://www.frontiersin.org/articles/10.3389/fonc.2022.988290/fullBranched chain amino transferase (BCAT)Branched-chain amino acids (BCAA)cancertargettumor resistance |
| spellingShingle | Xiazhen Nong Xiazhen Nong Caiyun Zhang Junmin Wang Peilun Ding Guang Ji Tao Wu The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects Frontiers in Oncology Branched chain amino transferase (BCAT) Branched-chain amino acids (BCAA) cancer target tumor resistance |
| title | The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects |
| title_full | The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects |
| title_fullStr | The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects |
| title_full_unstemmed | The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects |
| title_short | The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects |
| title_sort | mechanism of branched chain amino acid transferases in different diseases research progress and future prospects |
| topic | Branched chain amino transferase (BCAT) Branched-chain amino acids (BCAA) cancer target tumor resistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.988290/full |
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