Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment
Vitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was synthesized. These polymer nanoparticles were...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2023-01-01
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| Series: | Materials Research Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2053-1591/ad0d31 |
| _version_ | 1797447612130918400 |
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| author | Zhuoran Li Huikang Yang Fan Xu Xuwen Zeng Haowei Huang Xinqing Jiang |
| author_facet | Zhuoran Li Huikang Yang Fan Xu Xuwen Zeng Haowei Huang Xinqing Jiang |
| author_sort | Zhuoran Li |
| collection | DOAJ |
| description | Vitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was synthesized. These polymer nanoparticles were utilized as theranostic agents for tumor-targeted magnetic resonance imaging (MRI) and chemotherapy. By loading doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) particles into TPGS nanoparticles, FA-SS-TPGS@DOX/SPIO nanoparticles are obtained. In vitro drug release studies revealed that under a reducing environment in the presence of glutathione (GSH), approximately 100% of the doxorubicin (DOX) was released from the disulfide bond-linked theranostic nanoparticles within 24 h. DOX and SPIO were efficiently delivered into HepG2-ADM cells due to the folate receptor-mediated endocytosis process of the nanoparticles. Additionally, the presence of glutathione (GSH) triggered the cleaving of the disulfide bonds, further facilitating the delivery of DOX and SPIO into the cells. Furthermore, the FA-SS-TPGS @DOX-SPIO nanoparticles exhibited strong MRI contrast enhancement properties. In conclusion, FA-SS-TPGS@DOX/SPIO are potential nanoparticles for tumor-targeted MRI and chemotherapy, which can also overcome multidrug resistance. |
| first_indexed | 2024-03-09T13:58:26Z |
| format | Article |
| id | doaj.art-cdddf94a52e4446ab5104df6f2587294 |
| institution | Directory Open Access Journal |
| issn | 2053-1591 |
| language | English |
| last_indexed | 2024-03-09T13:58:26Z |
| publishDate | 2023-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj.art-cdddf94a52e4446ab5104df6f25872942023-11-30T11:51:16ZengIOP PublishingMaterials Research Express2053-15912023-01-01101111540410.1088/2053-1591/ad0d31Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatmentZhuoran Li0https://orcid.org/0000-0002-5236-1575Huikang Yang1Fan Xu2Xuwen Zeng3Haowei Huang4https://orcid.org/0000-0002-8029-1981Xinqing Jiang5Department of Radiology, Guangzhou Red Cross Hospital of Jinan University , Guangzhou, Guangdong, People’s Republic of ChinaDepartment of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology , Guangzhou, Guangdong, People’s Republic of ChinaDepartment of Radiology, Guangzhou Red Cross Hospital of Jinan University , Guangzhou, Guangdong, People’s Republic of ChinaDepartment of Radiology, Guangzhou Red Cross Hospital of Jinan University , Guangzhou, Guangdong, People’s Republic of ChinaDepartment of Radiotherapy, Guangzhou Red Cross Hospital of Jinan University , Guangzhou, Guangdong, People’s Republic of ChinaDepartment of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology , Guangzhou, Guangdong, People’s Republic of China; Department of Radiology, Guangzhou First People’s Hospital, Jinan University , Guangzhou, Guangdong, People’s Republic of ChinaVitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was synthesized. These polymer nanoparticles were utilized as theranostic agents for tumor-targeted magnetic resonance imaging (MRI) and chemotherapy. By loading doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) particles into TPGS nanoparticles, FA-SS-TPGS@DOX/SPIO nanoparticles are obtained. In vitro drug release studies revealed that under a reducing environment in the presence of glutathione (GSH), approximately 100% of the doxorubicin (DOX) was released from the disulfide bond-linked theranostic nanoparticles within 24 h. DOX and SPIO were efficiently delivered into HepG2-ADM cells due to the folate receptor-mediated endocytosis process of the nanoparticles. Additionally, the presence of glutathione (GSH) triggered the cleaving of the disulfide bonds, further facilitating the delivery of DOX and SPIO into the cells. Furthermore, the FA-SS-TPGS @DOX-SPIO nanoparticles exhibited strong MRI contrast enhancement properties. In conclusion, FA-SS-TPGS@DOX/SPIO are potential nanoparticles for tumor-targeted MRI and chemotherapy, which can also overcome multidrug resistance.https://doi.org/10.1088/2053-1591/ad0d31multidrug resistanceTPGStumor-targeteddisulfide bondtheranostic nanoparticles |
| spellingShingle | Zhuoran Li Huikang Yang Fan Xu Xuwen Zeng Haowei Huang Xinqing Jiang Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment Materials Research Express multidrug resistance TPGS tumor-targeted disulfide bond theranostic nanoparticles |
| title | Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment |
| title_full | Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment |
| title_fullStr | Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment |
| title_full_unstemmed | Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment |
| title_short | Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment |
| title_sort | folic acid decorated vitamin e poly ethylene glycol monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment |
| topic | multidrug resistance TPGS tumor-targeted disulfide bond theranostic nanoparticles |
| url | https://doi.org/10.1088/2053-1591/ad0d31 |
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