The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

ABSTRACT Many studies of Mycobacterium tuberculosis infection and immunity have used mouse models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred mouse strains do not reflect the full range of outcomes seen in people. Previous studies indicated that the novel Diversity...

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Bibliographic Details
Main Authors: Sherry L. Kurtz, Amy P. Rossi, Gillian L. Beamer, Dan M. Gatti, Igor Kramnik, Karen L. Elkins
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mSphere
Subjects:
Mycobacterium tuberculosis
animal models
Diversity Outbred
immunization
tuberculosis vaccines
vaccines
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00097-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00097-20

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