A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways involved in tumor progres...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/7/1852 |
| _version_ | 1797562875309457408 |
|---|---|
| author | Alexis Forterre Hiroaki Komuro Shakhlo Aminova Masako Harada |
| author_facet | Alexis Forterre Hiroaki Komuro Shakhlo Aminova Masako Harada |
| author_sort | Alexis Forterre |
| collection | DOAJ |
| description | In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways involved in tumor progression, invasion, angiogenesis and metastasis in a wide range of cancer types. Hence, altering miRNA levels in cancer cells has promising potential as a therapeutic intervention, which is discussed in many other articles in this Special Issue. Some of the most significant hurdles in therapeutic miRNA usage are the stability and the delivery system. In this review, we cover a comprehensive update on the challenges and strategies for the development of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (artificial lipid-based vesicles, polymer-based or chemical structures), and recently emerged extracellular vesicle (EV)-based delivery systems. |
| first_indexed | 2024-03-10T18:35:00Z |
| format | Article |
| id | doaj.art-cde090a7f5d0444ebdf96e21a1d1cdaf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:35:00Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cde090a7f5d0444ebdf96e21a1d1cdaf2023-11-20T06:19:16ZengMDPI AGCancers2072-66942020-07-01127185210.3390/cancers12071852A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery StrategiesAlexis Forterre0Hiroaki Komuro1Shakhlo Aminova2Masako Harada3UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, 67200 Strasbourg, FranceDepartment of Cardiovascular Physiology, Tokyo Medical and Dental University, Tokyo 113-8510, JapanLyman Briggs College, Michigan State University, East Lansing, MI 48825, USAInstitute for Quantitative Health Sciences and Engineering (IQ), Michigan State University, East Lansing, MI 48824, USAIn the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways involved in tumor progression, invasion, angiogenesis and metastasis in a wide range of cancer types. Hence, altering miRNA levels in cancer cells has promising potential as a therapeutic intervention, which is discussed in many other articles in this Special Issue. Some of the most significant hurdles in therapeutic miRNA usage are the stability and the delivery system. In this review, we cover a comprehensive update on the challenges and strategies for the development of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (artificial lipid-based vesicles, polymer-based or chemical structures), and recently emerged extracellular vesicle (EV)-based delivery systems.https://www.mdpi.com/2072-6694/12/7/1852microRNA deliverycancer therapytherapeutic RNAextracellular vesicles |
| spellingShingle | Alexis Forterre Hiroaki Komuro Shakhlo Aminova Masako Harada A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies Cancers microRNA delivery cancer therapy therapeutic RNA extracellular vesicles |
| title | A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies |
| title_full | A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies |
| title_fullStr | A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies |
| title_full_unstemmed | A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies |
| title_short | A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies |
| title_sort | comprehensive review of cancer microrna therapeutic delivery strategies |
| topic | microRNA delivery cancer therapy therapeutic RNA extracellular vesicles |
| url | https://www.mdpi.com/2072-6694/12/7/1852 |
| work_keys_str_mv | AT alexisforterre acomprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT hiroakikomuro acomprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT shakhloaminova acomprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT masakoharada acomprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT alexisforterre comprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT hiroakikomuro comprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT shakhloaminova comprehensivereviewofcancermicrornatherapeuticdeliverystrategies AT masakoharada comprehensivereviewofcancermicrornatherapeuticdeliverystrategies |