Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia
Introduction: Several pharmacological and non-pharmacological ways have been used to prevent Post-Operative Sore Throat (POST). Post-Operative Sore Throat (POST) can be prevented with or without medical management. Dexmedetomidine is a selective alpha 2 adrenergic agonists which can be used for pre-...
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JCDR Research and Publications Private Limited
2023-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/18117/60677_CE[Ra1]_F(IS)_PF1(AS_IS)_PN_(KM).pdf |
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| author | Subha Teresa Jose Vazhakalayil Shilpa Kore Anilin Joey Deepu Palal |
| author_facet | Subha Teresa Jose Vazhakalayil Shilpa Kore Anilin Joey Deepu Palal |
| author_sort | Subha Teresa Jose Vazhakalayil |
| collection | DOAJ |
| description | Introduction: Several pharmacological and non-pharmacological ways have been used to prevent Post-Operative Sore Throat (POST). Post-Operative Sore Throat (POST) can be prevented with or without medical management. Dexmedetomidine is a selective alpha 2 adrenergic agonists which can be used for pre-operative nebulization to prevent POST. Dexmedetomidine absorption will be greater through transmucosal route as it is a highly lipid soluble agent. It is a highly lipid soluble agent with good systemic absorption during transmucosal administration.
Aim: To assess the efficacy of dexmedetomidine nebulisation in reducing POST in patient who require general anaesthesia with endotracheal intubation.
Materials and Methods: This randomized control study was conducted from January 2022 to March 2022. There were 60 patients separated into 2 groups and 30 patients in each. The patients were of age more than 18 years and belonged to American society of Anesthesiology (ASA) grade I and II, posted for elective surgery under general anesthesia. Group D was given dexmedetomidine 50 mcg (1 ml) with 3 ml of saline and made it total volume of 4 ml nebulisation and Group C was given 4 ml of saline nebulisation. Sore throat was evaluated at 0, 2nd,4th,6th,12th and 24th hour after extubation, during the post-operative period.
Results: Mean age (SD) of patients in group D was 33.5±12.9 years and that in group C was 36.83±14.5years (P value=0.23). During post operative period, the severeness of sore throat was remarkably lesser in Group D especially from 4th hour upto 24th hour. Severeness of POST was remarkably lesser in group D compared to group C patients over the 4th -24th hours.
Conclusion: Dexmedetomidine nebulisation given prior to surgery is beneficial in reducing POST, with minimal haemodynamic disturbance. Dexmedetomidine in nebulised form is therefore a safe option for lowering POST. |
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| language | English |
| last_indexed | 2024-03-13T01:27:31Z |
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| spelling | doaj.art-cde0a51fffd6451189c0e32d593e46b82023-07-04T13:29:13ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-06-01176UC55UC5710.7860/JCDR/2023/60677.18117Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General AnaesthesiaSubha Teresa Jose Vazhakalayil0Shilpa Kore1Anilin Joey2Deepu Palal3Associate Professor, Department of Anaesthesiology, Dr. DY Patil Medical College, Hospital, Research Centre, Dr. DY Patil Vidyapeeth Pimpri, Pune, Maharashtra, India.Associate Professor, Department of Anaesthesiology, Dr. DY Patil Medical College, Hospital, Research Centre, Dr. DY Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India. Third Year Resident, DepartmentofAnaesthesiology, Dr. DY Patil Medical College, Hospital, Research Centre, Dr. DY Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.Resident, Department of Preventive and Social Medicine, Dr. DY Patil Medical College, Hospital, Research Centre, Dr. DY Patil Vedyapeeth, Pimpri, Pune, Maharashtra, India.Introduction: Several pharmacological and non-pharmacological ways have been used to prevent Post-Operative Sore Throat (POST). Post-Operative Sore Throat (POST) can be prevented with or without medical management. Dexmedetomidine is a selective alpha 2 adrenergic agonists which can be used for pre-operative nebulization to prevent POST. Dexmedetomidine absorption will be greater through transmucosal route as it is a highly lipid soluble agent. It is a highly lipid soluble agent with good systemic absorption during transmucosal administration. Aim: To assess the efficacy of dexmedetomidine nebulisation in reducing POST in patient who require general anaesthesia with endotracheal intubation. Materials and Methods: This randomized control study was conducted from January 2022 to March 2022. There were 60 patients separated into 2 groups and 30 patients in each. The patients were of age more than 18 years and belonged to American society of Anesthesiology (ASA) grade I and II, posted for elective surgery under general anesthesia. Group D was given dexmedetomidine 50 mcg (1 ml) with 3 ml of saline and made it total volume of 4 ml nebulisation and Group C was given 4 ml of saline nebulisation. Sore throat was evaluated at 0, 2nd,4th,6th,12th and 24th hour after extubation, during the post-operative period. Results: Mean age (SD) of patients in group D was 33.5±12.9 years and that in group C was 36.83±14.5years (P value=0.23). During post operative period, the severeness of sore throat was remarkably lesser in Group D especially from 4th hour upto 24th hour. Severeness of POST was remarkably lesser in group D compared to group C patients over the 4th -24th hours. Conclusion: Dexmedetomidine nebulisation given prior to surgery is beneficial in reducing POST, with minimal haemodynamic disturbance. Dexmedetomidine in nebulised form is therefore a safe option for lowering POST.https://jcdr.net/articles/PDF/18117/60677_CE[Ra1]_F(IS)_PF1(AS_IS)_PN_(KM).pdfexmedetomidinegeneral anaesthesianebulisationsore throat |
| spellingShingle | Subha Teresa Jose Vazhakalayil Shilpa Kore Anilin Joey Deepu Palal Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia Journal of Clinical and Diagnostic Research exmedetomidine general anaesthesia nebulisation sore throat |
| title | Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia |
| title_full | Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia |
| title_fullStr | Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia |
| title_full_unstemmed | Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia |
| title_short | Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia |
| title_sort | preoperative nebulisation with dexmedetomidine to prevent postoperative sore throat in patients undergoing general anaesthesia |
| topic | exmedetomidine general anaesthesia nebulisation sore throat |
| url | https://jcdr.net/articles/PDF/18117/60677_CE[Ra1]_F(IS)_PF1(AS_IS)_PN_(KM).pdf |
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