Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States
Background: Human adenovirus (HAdV)-D56 was first described in 2011 by genomics analysis of a strain isolated in France in 2008 from a fatal case of neonatal infection. Since then, it has been reported in cases of keratoconjunctivitis and male urethritis. Three epidemiologically unrelated fatal case...
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MDPI AG
2021-06-01
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1105 |
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| author | William R. Otto Daryl M. Lamson Gabriel Gonzalez Geoffrey A. Weinberg Nicole D. Pecora Brian T. Fisher Kirsten St. George Adriana E. Kajon |
| author_facet | William R. Otto Daryl M. Lamson Gabriel Gonzalez Geoffrey A. Weinberg Nicole D. Pecora Brian T. Fisher Kirsten St. George Adriana E. Kajon |
| author_sort | William R. Otto |
| collection | DOAJ |
| description | Background: Human adenovirus (HAdV)-D56 was first described in 2011 by genomics analysis of a strain isolated in France in 2008 from a fatal case of neonatal infection. Since then, it has been reported in cases of keratoconjunctivitis and male urethritis. Three epidemiologically unrelated fatal cases of neonatal sepsis associated with infection by HAdV-D strains with a similar genetic makeup were documented in the United States between 2014 and 2020. Methods: Whole genome sequences were obtained for the isolated strains, and genomics analyses were conducted to compare them to phylogenetically related HAdV-D genomic sequences available in GenBank. Results: The three new US strains were indistinguishable by in silico restriction enzyme analysis. Their genome sequences were 99.9% identical to one another and to the prototype strain isolated in 2008 from a similar context of disease. The phylogenetic reconstruction revealed a highly supported clustering of all HAdV-D56 strains isolated in various countries since 1982. Our comparison to serologically intermediate strains 15/H9 described in the literature indicated that HAdV-D56-like viruses have circulated worldwide since the late 1950s. Conclusion: As with other HAdV-D genotypes with the ability to infect ocular and genital mucosae, the risk of severe prenatal or perinatal HAdV-D56 infection must be considered. |
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| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:34:31Z |
| publishDate | 2021-06-01 |
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| series | Viruses |
| spelling | doaj.art-cde0af1b69524739ab95df5fd1fb918c2023-11-21T23:26:27ZengMDPI AGViruses1999-49152021-06-01136110510.3390/v13061105Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United StatesWilliam R. Otto0Daryl M. Lamson1Gabriel Gonzalez2Geoffrey A. Weinberg3Nicole D. Pecora4Brian T. Fisher5Kirsten St. George6Adriana E. Kajon7Division of Infectious Diseases, Department of Pediatrics, The Children’s Hospital of Philadelphia (CHOP), Philadelphia, PA 19104, USAWadsworth Center, New York State Department of Health (WC-NYSDOH), Albany, NY 12201, USANational Virus Reference Laboratory (NVRL), University College Dublin, D04 V1W8 Dublin, IrelandDepartment of Pediatrics, University of Rochester School of Medicine & Dentistry Rochester (UoR), Rochester, NY 14642, USADepartment of Pathology and Laboratory Medicine, UoR, Rochester, NY 14642, USADivision of Infectious Diseases, Department of Pediatrics, The Children’s Hospital of Philadelphia (CHOP), Philadelphia, PA 19104, USAWadsworth Center, New York State Department of Health (WC-NYSDOH), Albany, NY 12201, USALovelace Biomedical Research Institute, Albuquerque, NM 87108, USABackground: Human adenovirus (HAdV)-D56 was first described in 2011 by genomics analysis of a strain isolated in France in 2008 from a fatal case of neonatal infection. Since then, it has been reported in cases of keratoconjunctivitis and male urethritis. Three epidemiologically unrelated fatal cases of neonatal sepsis associated with infection by HAdV-D strains with a similar genetic makeup were documented in the United States between 2014 and 2020. Methods: Whole genome sequences were obtained for the isolated strains, and genomics analyses were conducted to compare them to phylogenetically related HAdV-D genomic sequences available in GenBank. Results: The three new US strains were indistinguishable by in silico restriction enzyme analysis. Their genome sequences were 99.9% identical to one another and to the prototype strain isolated in 2008 from a similar context of disease. The phylogenetic reconstruction revealed a highly supported clustering of all HAdV-D56 strains isolated in various countries since 1982. Our comparison to serologically intermediate strains 15/H9 described in the literature indicated that HAdV-D56-like viruses have circulated worldwide since the late 1950s. Conclusion: As with other HAdV-D genotypes with the ability to infect ocular and genital mucosae, the risk of severe prenatal or perinatal HAdV-D56 infection must be considered.https://www.mdpi.com/1999-4915/13/6/1105adenovirusneonatal sepsisgenomicsintermediate strainspecies HAdV-D |
| spellingShingle | William R. Otto Daryl M. Lamson Gabriel Gonzalez Geoffrey A. Weinberg Nicole D. Pecora Brian T. Fisher Kirsten St. George Adriana E. Kajon Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States Viruses adenovirus neonatal sepsis genomics intermediate strain species HAdV-D |
| title | Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States |
| title_full | Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States |
| title_fullStr | Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States |
| title_full_unstemmed | Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States |
| title_short | Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States |
| title_sort | fatal neonatal sepsis associated with human adenovirus type 56 infection genomic analysis of three recent cases detected in the united states |
| topic | adenovirus neonatal sepsis genomics intermediate strain species HAdV-D |
| url | https://www.mdpi.com/1999-4915/13/6/1105 |
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