Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series
Aim: Long-term survivors (LTS) after glioma recurrence while on bevacizumab (Bev) therapy are rarely reported in the current literature. The purpose of this case series is to confirm the existence of and describe a large cohort of recurrent glioma LTS treated with Bev (Bev-LTS). Patients & metho...
| Autori principali: | , , , , , , , , , , , |
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| Natura: | Articolo |
| Lingua: | English |
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Taylor & Francis Group
2019-06-01
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| Serie: | CNS Oncology |
| Soggetti: | |
| Accesso online: | https://www.futuremedicine.com/doi/10.2217/cns-2019-0007 |
| _version_ | 1826992128672137216 |
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| author | Liang Yen Liu Matthew S Ji Nhung T Nguyen Frances E Chow Donna M Molaie Sean T Pianka Richard M Green Linda M Liau Benjamin M Ellingson Phioanh L Nghiemphu Timothy F Cloughesy Albert Lai |
| author_facet | Liang Yen Liu Matthew S Ji Nhung T Nguyen Frances E Chow Donna M Molaie Sean T Pianka Richard M Green Linda M Liau Benjamin M Ellingson Phioanh L Nghiemphu Timothy F Cloughesy Albert Lai |
| author_sort | Liang Yen Liu |
| collection | DOAJ |
| description | Aim: Long-term survivors (LTS) after glioma recurrence while on bevacizumab (Bev) therapy are rarely reported in the current literature. The purpose of this case series is to confirm the existence of and describe a large cohort of recurrent glioma LTS treated with Bev (Bev-LTS). Patients & methods: We identified Bev-LTS as patients with post-Bev initiation survival times of ≥3 years among 1397 Bev treated recurrent glioma patients. Results: Among 962 grade-IV, 221 grade III, and 214 grade II Bev-treated glioma patients, we identified 28 (2.9%), 14 (6.3%) and 8 (3.7%) Bev-LTS patients, respectively. 45 Bev-LTS patients recurred on Bev, with 36 of those patients continuing therapy. Conclusion: Our study shows that a small portion of grade-IV, -III, and -II glioma patients can have long-term survival on Bev therapy even after Bev recurrence. |
| first_indexed | 2025-02-18T08:45:02Z |
| format | Article |
| id | doaj.art-cde7ec1c69ac44e7b15af2ee6e86cad6 |
| institution | Directory Open Access Journal |
| issn | 2045-0907 2045-0915 |
| language | English |
| last_indexed | 2025-02-18T08:45:02Z |
| publishDate | 2019-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CNS Oncology |
| spelling | doaj.art-cde7ec1c69ac44e7b15af2ee6e86cad62024-11-03T00:13:15ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152019-06-018210.2217/cns-2019-0007Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case seriesLiang Yen Liu0Matthew S Ji1Nhung T Nguyen2Frances E Chow3Donna M Molaie4Sean T Pianka5Richard M Green6Linda M Liau7Benjamin M Ellingson8Phioanh L Nghiemphu9Timothy F Cloughesy10Albert Lai111Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA2Department of Neurology, Kaiser Permanente, Southern California, 4867 W Sunset Blvd, Los Angeles, CA 90027, US3Department of Neurosurgery, University of California, Los Angeles, Edie & Lew Wasserman Building, 300 Stein Plaza, Ste. 420, Los Angeles, CA 90095, USA4Department of Radiological Sciences & Psychiatry, University of California, Los Angeles, 924 Westwood Blvd, Ste. 615, Los Angeles, CA 90024, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USA1Department of Neurology, University of California, Los Angeles, 710 Westwood Plaza RNRC #1–230, Los Angeles, CA 90095, USAAim: Long-term survivors (LTS) after glioma recurrence while on bevacizumab (Bev) therapy are rarely reported in the current literature. The purpose of this case series is to confirm the existence of and describe a large cohort of recurrent glioma LTS treated with Bev (Bev-LTS). Patients & methods: We identified Bev-LTS as patients with post-Bev initiation survival times of ≥3 years among 1397 Bev treated recurrent glioma patients. Results: Among 962 grade-IV, 221 grade III, and 214 grade II Bev-treated glioma patients, we identified 28 (2.9%), 14 (6.3%) and 8 (3.7%) Bev-LTS patients, respectively. 45 Bev-LTS patients recurred on Bev, with 36 of those patients continuing therapy. Conclusion: Our study shows that a small portion of grade-IV, -III, and -II glioma patients can have long-term survival on Bev therapy even after Bev recurrence.https://www.futuremedicine.com/doi/10.2217/cns-2019-0007bevacizumabglioblastomagliomalong termprogressionrecurrence |
| spellingShingle | Liang Yen Liu Matthew S Ji Nhung T Nguyen Frances E Chow Donna M Molaie Sean T Pianka Richard M Green Linda M Liau Benjamin M Ellingson Phioanh L Nghiemphu Timothy F Cloughesy Albert Lai Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series CNS Oncology bevacizumab glioblastoma glioma long term progression recurrence |
| title | Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series |
| title_full | Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series |
| title_fullStr | Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series |
| title_full_unstemmed | Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series |
| title_short | Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series |
| title_sort | patterns of long term survivorship following bevacizumab treatment for recurrent glioma a case series |
| topic | bevacizumab glioblastoma glioma long term progression recurrence |
| url | https://www.futuremedicine.com/doi/10.2217/cns-2019-0007 |
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