The role of pyroptosis in inflammatory diseases
Programmed cell death has crucial roles in the physiological maturation of an organism, the maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed cell death which has recently received much attention, is closely related to inflammation and occurs via canonical, non-can...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1173235/full |
| _version_ | 1797828960225067008 |
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| author | Rong Chai Ying Li Linna Shui Longxing Ni Ansheng Zhang |
| author_facet | Rong Chai Ying Li Linna Shui Longxing Ni Ansheng Zhang |
| author_sort | Rong Chai |
| collection | DOAJ |
| description | Programmed cell death has crucial roles in the physiological maturation of an organism, the maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed cell death which has recently received much attention, is closely related to inflammation and occurs via canonical, non-canonical, caspase-3-dependent, and unclassified pathways. The pore-forming gasdermin proteins mediate pyroptosis by promoting cell lysis, contributing to the outflow of large amounts of inflammatory cytokines and cellular contents. Although the inflammatory response is critical for the body’s defense against pathogens, uncontrolled inflammation can cause tissue damage and is a vital factor in the occurrence and progression of various diseases. In this review, we briefly summarize the major signaling pathways of pyroptosis and discuss current research on the pathological function of pyroptosis in autoinflammatory diseases and sterile inflammatory diseases. |
| first_indexed | 2024-04-09T13:12:46Z |
| format | Article |
| id | doaj.art-cde80932cfe94fc0898fbf1ae7b951aa |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T13:12:46Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-cde80932cfe94fc0898fbf1ae7b951aa2023-05-12T06:06:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.11732351173235The role of pyroptosis in inflammatory diseasesRong ChaiYing LiLinna ShuiLongxing NiAnsheng ZhangProgrammed cell death has crucial roles in the physiological maturation of an organism, the maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed cell death which has recently received much attention, is closely related to inflammation and occurs via canonical, non-canonical, caspase-3-dependent, and unclassified pathways. The pore-forming gasdermin proteins mediate pyroptosis by promoting cell lysis, contributing to the outflow of large amounts of inflammatory cytokines and cellular contents. Although the inflammatory response is critical for the body’s defense against pathogens, uncontrolled inflammation can cause tissue damage and is a vital factor in the occurrence and progression of various diseases. In this review, we briefly summarize the major signaling pathways of pyroptosis and discuss current research on the pathological function of pyroptosis in autoinflammatory diseases and sterile inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fcell.2023.1173235/fullpyroptosisinflammasomeprogramed cell deathinflammationdental pulp fibroblasts |
| spellingShingle | Rong Chai Ying Li Linna Shui Longxing Ni Ansheng Zhang The role of pyroptosis in inflammatory diseases Frontiers in Cell and Developmental Biology pyroptosis inflammasome programed cell death inflammation dental pulp fibroblasts |
| title | The role of pyroptosis in inflammatory diseases |
| title_full | The role of pyroptosis in inflammatory diseases |
| title_fullStr | The role of pyroptosis in inflammatory diseases |
| title_full_unstemmed | The role of pyroptosis in inflammatory diseases |
| title_short | The role of pyroptosis in inflammatory diseases |
| title_sort | role of pyroptosis in inflammatory diseases |
| topic | pyroptosis inflammasome programed cell death inflammation dental pulp fibroblasts |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1173235/full |
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