Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study
Background The association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger onset age of CHD is associated with a higher risk of incident dementia. Methods and Results Data were obtained from the UK Biobank. Informati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.031407 |
| _version_ | 1797403668506476544 |
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| author | Jie Liang Chenglong Li Darui Gao Qian Ma Yongqian Wang Yang Pan Wenya Zhang Wuxiang Xie Fanfan Zheng |
| author_facet | Jie Liang Chenglong Li Darui Gao Qian Ma Yongqian Wang Yang Pan Wenya Zhang Wuxiang Xie Fanfan Zheng |
| author_sort | Jie Liang |
| collection | DOAJ |
| description | Background The association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger onset age of CHD is associated with a higher risk of incident dementia. Methods and Results Data were obtained from the UK Biobank. Information on the diagnosis of CHD and dementia was collected at baseline and follow‐ups. Propensity score matching method and Cox proportional hazards models were used to evaluate the association between different ages at CHD onset and incident dementia. A total of 432 667 adults (mean±SD age, 56.9±8.1 years) were included, of whom 11.7% had CHD. Compared with participants without CHD, participants with CHD exhibited higher risks of developing all‐cause dementia, Alzheimer's disease, and vascular dementia. More importantly, younger age at CHD onset (per 10‐year decrease) was significantly associated with elevated risks of all‐cause dementia (hazard ratio [HR], 1.25 [95% CI, 1.20–1.30]; P<0.001), Alzheimer's disease (HR, 1.29 [95% CI, 1.20–1.38]; P<0.001), and vascular dementia (HR, 1.22 [95% CI, 1.13–1.31]; P<0.001). After propensity score matching, patients with CHD had significantly higher risks of all‐cause dementia, Alzheimer's disease, and vascular dementia than matched controls among all onset age groups, and the HRs gradually elevated with decreasing age at CHD onset. Conclusions Younger onset age of CHD is associated with higher risks of incident all‐cause dementia, Alzheimer's disease, and vascular dementia, underscoring the necessity to pay attention to the neurocognitive status of individuals diagnosed with CHD at younger age to conduct timely interventions to attenuate subsequent risk of incident dementia. |
| first_indexed | 2024-03-09T02:42:42Z |
| format | Article |
| id | doaj.art-cde8e2fd26984d7485819e99703cbecc |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-09T02:42:42Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-cde8e2fd26984d7485819e99703cbecc2023-12-06T02:49:39ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-12-01122310.1161/JAHA.123.031407Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort StudyJie Liang0Chenglong Li1Darui Gao2Qian Ma3Yongqian Wang4Yang Pan5Wenya Zhang6Wuxiang Xie7Fanfan Zheng8Department of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing ChinaHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing ChinaDepartment of Cardiology, Beijing Anzhen Hospital Capital Medical University Beijing ChinaHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing ChinaDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing ChinaDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaBackground The association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger onset age of CHD is associated with a higher risk of incident dementia. Methods and Results Data were obtained from the UK Biobank. Information on the diagnosis of CHD and dementia was collected at baseline and follow‐ups. Propensity score matching method and Cox proportional hazards models were used to evaluate the association between different ages at CHD onset and incident dementia. A total of 432 667 adults (mean±SD age, 56.9±8.1 years) were included, of whom 11.7% had CHD. Compared with participants without CHD, participants with CHD exhibited higher risks of developing all‐cause dementia, Alzheimer's disease, and vascular dementia. More importantly, younger age at CHD onset (per 10‐year decrease) was significantly associated with elevated risks of all‐cause dementia (hazard ratio [HR], 1.25 [95% CI, 1.20–1.30]; P<0.001), Alzheimer's disease (HR, 1.29 [95% CI, 1.20–1.38]; P<0.001), and vascular dementia (HR, 1.22 [95% CI, 1.13–1.31]; P<0.001). After propensity score matching, patients with CHD had significantly higher risks of all‐cause dementia, Alzheimer's disease, and vascular dementia than matched controls among all onset age groups, and the HRs gradually elevated with decreasing age at CHD onset. Conclusions Younger onset age of CHD is associated with higher risks of incident all‐cause dementia, Alzheimer's disease, and vascular dementia, underscoring the necessity to pay attention to the neurocognitive status of individuals diagnosed with CHD at younger age to conduct timely interventions to attenuate subsequent risk of incident dementia.https://www.ahajournals.org/doi/10.1161/JAHA.123.031407coronary heart diseasedementiaonset agepropensity score matchingUK Biobank |
| spellingShingle | Jie Liang Chenglong Li Darui Gao Qian Ma Yongqian Wang Yang Pan Wenya Zhang Wuxiang Xie Fanfan Zheng Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease coronary heart disease dementia onset age propensity score matching UK Biobank |
| title | Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study |
| title_full | Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study |
| title_fullStr | Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study |
| title_full_unstemmed | Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study |
| title_short | Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study |
| title_sort | association between onset age of coronary heart disease and incident dementia a prospective cohort study |
| topic | coronary heart disease dementia onset age propensity score matching UK Biobank |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.031407 |
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