Evaluating the effect of acute diesel exhaust particle exposure on P-glycoprotein efflux transporter in the blood–brain barrier co-cultured with microglia

Evaluating the effect of acute diesel exhaust particle exposure on P-glycoprotein efflux transporter in the blood–brain barrier co-cultured with microglia

A growing public health concern, chronic Diesel Exhaust Particle (DEP) exposure is a heavy risk factor for the development of neurodegenerative diseases like Alzheimer’s (AD). Considered the brain’s first line of defense, the Blood–Brain Barrier (BBB) and perivascular microglia work in tandem to pro...

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Bibliographic Details
Main Authors: Grace V. Aquino, Amjad Dabi, Gabriel J. Odom, Ramon Lavado, Kaitlin Nunn, Kathryn Thomas, Bennett Schackmuth, Nazeel Shariff, Manogna Jarajapu, Morgan Pluto, Sara R. Miller, Leah Eller, Justin Pressley, Rishi R. Patel, Jeffrey Black, Erica D. Bruce
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Toxicology
Subjects:
Diesel exhaust particles
Blood–brain barrier
P-glycoprotein
Amyloid-beta
Inflammation
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X23000051

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