Interaction Analysis Reveals Complex Genetic Associations with Alzheimer’s Disease in the <i>CLU</i> and <i>ABCA7</i> Gene Regions

Interaction Analysis Reveals Complex Genetic Associations with Alzheimer’s Disease in the <i>CLU</i> and <i>ABCA7</i> Gene Regions

Sporadic Alzheimer’s disease (AD) is a polygenic neurodegenerative disorder. Single-nucleotide polymorphisms (SNPs) in multiple genes (e.g., <i>CLU</i> and <i>ABCA7</i>) have been associated with AD. However, none of them were characterized as causal variants that indicate th...

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Bibliographic Details
Main Authors:	Alireza Nazarian, Brandon Cook, Marissa Morado, Alexander M. Kulminski
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Series:	Genes
Subjects:	dementia Aging SNPs interaction compound genotype genetic heterogeneity
Online Access:	https://www.mdpi.com/2073-4425/14/9/1666

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