MAP2K1 Mutation in Zebrafish Endothelial Cells Causes Arteriovenous Shunts Preventable by MEK Inhibition

MAP2K1 Mutation in Zebrafish Endothelial Cells Causes Arteriovenous Shunts Preventable by MEK Inhibition

Objectives:. Arteriovenous malformation (AVM) is a congenital lesion with a nidus of irregular blood vessels connecting arteries to veins instead of a normal capillary bed. Somatic MAP2K1 activating mutations in endothelial cells cause extracranial AVM. The purpose of this study was to create a MAP2...

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Bibliographic Details
Main Authors: Christopher L. Sudduth, Nicola Blum, Patrick J. Smits, Yu Sheng Cheng, Matthew P. Vivero, Matthew P. Harris, Nathan D. Lawson, Arin K. Greene
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2023-03-01
Series:Journal of Vascular Anomalies
Online Access:http://journals.lww.com/10.1097/JOVA.0000000000000063

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