Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger
Cardiovascular diseases are one of the leading causes of death and global health problems worldwide, and ischemic heart disease is the most common cause of heart failure (HF). The heart is a high-energy demanding organ, and myocardial energy reserves are limited. Mitochondria are the powerhouses of...
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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MDPI AG
2021-11-01
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| Σειρά: | Cells |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.mdpi.com/2073-4409/10/12/3330 |
| _version_ | 1827673611138236416 |
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| author | Justin D. Yu Shigeki Miyamoto |
| author_facet | Justin D. Yu Shigeki Miyamoto |
| author_sort | Justin D. Yu |
| collection | DOAJ |
| description | Cardiovascular diseases are one of the leading causes of death and global health problems worldwide, and ischemic heart disease is the most common cause of heart failure (HF). The heart is a high-energy demanding organ, and myocardial energy reserves are limited. Mitochondria are the powerhouses of the cell, but under stress conditions, they become damaged, release necrotic and apoptotic factors, and contribute to cell death. Loss of cardiomyocytes plays a significant role in ischemic heart disease. In response to stress, protective signaling pathways are activated to limit mitochondrial deterioration and protect the heart. To prevent mitochondrial death pathways, damaged mitochondria are removed by mitochondrial autophagy (mitophagy). Mitochondrial quality control mediated by mitophagy is functionally linked to mitochondrial dynamics. This review provides a current understanding of the signaling mechanisms by which the integrity of mitochondria is preserved in the heart against ischemic stress. |
| first_indexed | 2024-03-10T04:26:11Z |
| format | Article |
| id | doaj.art-cded538219154c8691f5bca90b38a3de |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:26:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-cded538219154c8691f5bca90b38a3de2023-11-23T07:36:19ZengMDPI AGCells2073-44092021-11-011012333010.3390/cells10123330Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in DangerJustin D. Yu0Shigeki Miyamoto1Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USADepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USACardiovascular diseases are one of the leading causes of death and global health problems worldwide, and ischemic heart disease is the most common cause of heart failure (HF). The heart is a high-energy demanding organ, and myocardial energy reserves are limited. Mitochondria are the powerhouses of the cell, but under stress conditions, they become damaged, release necrotic and apoptotic factors, and contribute to cell death. Loss of cardiomyocytes plays a significant role in ischemic heart disease. In response to stress, protective signaling pathways are activated to limit mitochondrial deterioration and protect the heart. To prevent mitochondrial death pathways, damaged mitochondria are removed by mitochondrial autophagy (mitophagy). Mitochondrial quality control mediated by mitophagy is functionally linked to mitochondrial dynamics. This review provides a current understanding of the signaling mechanisms by which the integrity of mitochondria is preserved in the heart against ischemic stress.https://www.mdpi.com/2073-4409/10/12/3330mitochondriacell deathBCL-2 family proteinsmPTPpro-survival signalingmitophagy |
| spellingShingle | Justin D. Yu Shigeki Miyamoto Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger Cells mitochondria cell death BCL-2 family proteins mPTP pro-survival signaling mitophagy |
| title | Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger |
| title_full | Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger |
| title_fullStr | Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger |
| title_full_unstemmed | Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger |
| title_short | Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger |
| title_sort | molecular signaling to preserve mitochondrial integrity against ischemic stress in the heart rescue or remove mitochondria in danger |
| topic | mitochondria cell death BCL-2 family proteins mPTP pro-survival signaling mitophagy |
| url | https://www.mdpi.com/2073-4409/10/12/3330 |
| work_keys_str_mv | AT justindyu molecularsignalingtopreservemitochondrialintegrityagainstischemicstressintheheartrescueorremovemitochondriaindanger AT shigekimiyamoto molecularsignalingtopreservemitochondrialintegrityagainstischemicstressintheheartrescueorremovemitochondriaindanger |