Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity

Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity

Increasing levels of oxidative-stress due to deterioration of the Nrf2 (NFE2-related factor)/ARE (antioxidant response element) pathway is found to be a primary cause of aging pathobiology. Metformin having anti-aging effects can delay/halt aging-related diseases. Herein, using lens epithelial cell...

Full description

Bibliographic Details
Main Authors: Bhavana Chhunchha, Eri Kubo, Dhirendra P. Singh
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
antioxidants
aging
oxidative stress
Peroxiredoxin 6
Metformin
age-related diseases
Online Access:https://www.mdpi.com/2073-4409/11/19/3021

Internet

https://www.mdpi.com/2073-4409/11/19/3021

Similar Items