Unraveling the therapeutic effects of mesenchymal stem cells in asthma
Abstract Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulm...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-020-01921-2 |
| _version_ | 1818341754083999744 |
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| author | Fatemeh Mirershadi Mahdi Ahmadi Aysa Rezabakhsh Hadi Rajabi Reza Rahbarghazi Rana Keyhanmanesh |
| author_facet | Fatemeh Mirershadi Mahdi Ahmadi Aysa Rezabakhsh Hadi Rajabi Reza Rahbarghazi Rana Keyhanmanesh |
| author_sort | Fatemeh Mirershadi |
| collection | DOAJ |
| description | Abstract Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases’ alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms. |
| first_indexed | 2024-12-13T16:03:49Z |
| format | Article |
| id | doaj.art-cdeec786cbae42b290aeccd799bd41de |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-13T16:03:49Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-cdeec786cbae42b290aeccd799bd41de2022-12-21T23:39:05ZengBMCStem Cell Research & Therapy1757-65122020-09-0111111210.1186/s13287-020-01921-2Unraveling the therapeutic effects of mesenchymal stem cells in asthmaFatemeh Mirershadi0Mahdi Ahmadi1Aysa Rezabakhsh2Hadi Rajabi3Reza Rahbarghazi4Rana Keyhanmanesh5Department of Physiology, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Physiology, Faculty of Medicine, Tabriz University of Medical SciencesCardiovascular Research Center, Tabriz University of Medical SciencesKoc University Research Center for Translational Medicine (KUTTAM), Koc University School of MedicineStem Cell Research Center, Tabriz University of Medical SciencesDepartment of Physiology, Faculty of Medicine, Tabriz University of Medical SciencesAbstract Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases’ alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms.http://link.springer.com/article/10.1186/s13287-020-01921-2Stem cellsAsthmaRegenerationCellular and molecular mechanisms |
| spellingShingle | Fatemeh Mirershadi Mahdi Ahmadi Aysa Rezabakhsh Hadi Rajabi Reza Rahbarghazi Rana Keyhanmanesh Unraveling the therapeutic effects of mesenchymal stem cells in asthma Stem Cell Research & Therapy Stem cells Asthma Regeneration Cellular and molecular mechanisms |
| title | Unraveling the therapeutic effects of mesenchymal stem cells in asthma |
| title_full | Unraveling the therapeutic effects of mesenchymal stem cells in asthma |
| title_fullStr | Unraveling the therapeutic effects of mesenchymal stem cells in asthma |
| title_full_unstemmed | Unraveling the therapeutic effects of mesenchymal stem cells in asthma |
| title_short | Unraveling the therapeutic effects of mesenchymal stem cells in asthma |
| title_sort | unraveling the therapeutic effects of mesenchymal stem cells in asthma |
| topic | Stem cells Asthma Regeneration Cellular and molecular mechanisms |
| url | http://link.springer.com/article/10.1186/s13287-020-01921-2 |
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