Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study

Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study

Background The genetically predicted lipid-lowering effect of HMGCR or PCSK9 variant can be used to assess drug proxy effects on kidney function. Methods Mendelian randomization (MR) analysis-identified HMGCR and PCSK9 genetic variants were used to predict the low-density lipoprotein (LDL) cholester...

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Main Authors: Sehoon Park, Seong Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Format: Article
Language:English
Published: The Korean Society of Nephrology 2023-07-01
Series:Kidney Research and Clinical Practice
Subjects:
chronic kidney disease
dyslipidaemia
mendelian randomization
statin
Online Access:http://www.krcp-ksn.org/upload/pdf/j-krcp-22-237.pdf

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