Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor
The present dataset contains the transcriptomic characterization of a novel in vitro model of non-alcoholic steatohepatitis (NASH) as well as its transcriptomics read-outs for the evaluation of elafibranor, a potential anti-NASH compound. We report whole genome microarray data (Affymetrix HG U133 pl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-08-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340919304470 |
| _version_ | 1828859941016829952 |
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| author | Joost Boeckmans Karolien Buyl Alessandra Natale Valerie Vandenbempt Steven Branson Veerle De Boe Vera Rogiers Joery De Kock Robim M. Rodrigues Tamara Vanhaecke |
| author_facet | Joost Boeckmans Karolien Buyl Alessandra Natale Valerie Vandenbempt Steven Branson Veerle De Boe Vera Rogiers Joery De Kock Robim M. Rodrigues Tamara Vanhaecke |
| author_sort | Joost Boeckmans |
| collection | DOAJ |
| description | The present dataset contains the transcriptomic characterization of a novel in vitro model of non-alcoholic steatohepatitis (NASH) as well as its transcriptomics read-outs for the evaluation of elafibranor, a potential anti-NASH compound. We report whole genome microarray data (Affymetrix HG U133 plus 2.0) of human multipotent stem cell-derived hepatic cells (hSKP-HPC) exposed to mediators of NASH. These cells were exposed to lipogenic inducers (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1β, TNF-α, TGF-β) to trigger hepatocellular responses characteristic of NASH. In addition, to evaluate the anti-NASH features of elafibranor, a dual peroxisome proliferator-activated receptor (PPAR) agonist that currently is under investigation as a potential anti-NASH therapeutic, was tested this in vitro set-up.This paper provides a detailed description of the microarray data as well as an indication of their value for evaluating cell signaling pathways (e.g. NFκB network) during the in vitro evaluation of anti-NASH compounds. Raw microarray data of different testing conditions were deposited as.CEL files in the Gene Expression Omnibus of NCBI with GEO Series accession number GSE126484. Further interpretation and discussion of these data can be found in the corresponding research article (DOI: 10.1016/j.phrs.2019.04.016) Boeckmans et al., 2019. Keywords: NASH, Elafibranor, In vitro, Transcriptomics |
| first_indexed | 2024-12-13T02:28:19Z |
| format | Article |
| id | doaj.art-cdfa3a1f73eb444eb5aa1427c40d706b |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-13T02:28:19Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-cdfa3a1f73eb444eb5aa1427c40d706b2022-12-22T00:02:34ZengElsevierData in Brief2352-34092019-08-0125Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranorJoost Boeckmans0Karolien Buyl1Alessandra Natale2Valerie Vandenbempt3Steven Branson4Veerle De Boe5Vera Rogiers6Joery De Kock7Robim M. Rodrigues8Tamara Vanhaecke9Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of Urology, UZ Brussel. Laarbeeklaan 101, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, Belgium; Corresponding author.Department of In Vitro Toxicology & Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel. Laarbeeklaan 103, 1090 Brussels, BelgiumThe present dataset contains the transcriptomic characterization of a novel in vitro model of non-alcoholic steatohepatitis (NASH) as well as its transcriptomics read-outs for the evaluation of elafibranor, a potential anti-NASH compound. We report whole genome microarray data (Affymetrix HG U133 plus 2.0) of human multipotent stem cell-derived hepatic cells (hSKP-HPC) exposed to mediators of NASH. These cells were exposed to lipogenic inducers (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1β, TNF-α, TGF-β) to trigger hepatocellular responses characteristic of NASH. In addition, to evaluate the anti-NASH features of elafibranor, a dual peroxisome proliferator-activated receptor (PPAR) agonist that currently is under investigation as a potential anti-NASH therapeutic, was tested this in vitro set-up.This paper provides a detailed description of the microarray data as well as an indication of their value for evaluating cell signaling pathways (e.g. NFκB network) during the in vitro evaluation of anti-NASH compounds. Raw microarray data of different testing conditions were deposited as.CEL files in the Gene Expression Omnibus of NCBI with GEO Series accession number GSE126484. Further interpretation and discussion of these data can be found in the corresponding research article (DOI: 10.1016/j.phrs.2019.04.016) Boeckmans et al., 2019. Keywords: NASH, Elafibranor, In vitro, Transcriptomicshttp://www.sciencedirect.com/science/article/pii/S2352340919304470 |
| spellingShingle | Joost Boeckmans Karolien Buyl Alessandra Natale Valerie Vandenbempt Steven Branson Veerle De Boe Vera Rogiers Joery De Kock Robim M. Rodrigues Tamara Vanhaecke Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor Data in Brief |
| title | Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor |
| title_full | Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor |
| title_fullStr | Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor |
| title_full_unstemmed | Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor |
| title_short | Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor |
| title_sort | transcriptomics data of a human in vitro model of non alcoholic steatohepatitis exposed to elafibranor |
| url | http://www.sciencedirect.com/science/article/pii/S2352340919304470 |
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