Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison

Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison

There is evidence suggesting that herbal extracts demonstrate greater bioactivities than their isolated constituents at an equivalent dose. This phenomenon could be attributed to the absence of interacting substances present in the extracts. By measuring the pharmacokinetic parameters of paeoniflori...

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Bibliographic Details
Main Authors: Weizhe Xu, Yan Zhao, Yi Qin, Beikang Ge, Wenwen Gong, Yingting Wu, Xiaorong Li, Yuming Zhao, Pingxiang Xu, Ming Xue
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
paeoniflorin
albiflorin
total peony glucosides
pharmacokinetics
interaction
hypoxic
UPLC-MS/MS
Online Access:http://www.mdpi.com/1420-3049/21/7/874

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