The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol
BackgroundPropofol injection pain is an unpleasant experience to patients and its prevalence can be influenced by age and gender. We determined the half maximal effective concentration (EC50) of remifentanil for preventing the microemulsion propofol injection pain in the male and female adult groups...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2012-12-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-63-504.pdf |
| _version_ | 1818259871964856320 |
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| author | Bo-Won Lee Sang-Hun Kim Keum-Young So |
| author_facet | Bo-Won Lee Sang-Hun Kim Keum-Young So |
| author_sort | Bo-Won Lee |
| collection | DOAJ |
| description | BackgroundPropofol injection pain is an unpleasant experience to patients and its prevalence can be influenced by age and gender. We determined the half maximal effective concentration (EC50) of remifentanil for preventing the microemulsion propofol injection pain in the male and female adult groups.MethodsAfter institutional review board approval, a total of 60 patients were assigned into 2 groups depending on their gender: group M (male, 20-65 yr) and group F (female, 20-65 yr). Anesthesia was induced with propofol and remifentanil, by a target-controlled infusion. Target effect-site concentration (Ce) of propofol and remifentanil for the first patient started at 4.0 ug/ml and 4.0 ng/ml. Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by the Dixon's up-and-down method (DUDM) with an interval of 0.2 ng/ml. After equilibration of plasma and effect site remifentanil concentration, propofol was administered, and the pain responses were observed.ResultsThe remifentanil EC50 was 3.8 ± 0.2 and 2.7 ± 0.2 ng/ml in groups M and F, respectively, by DUDM. From Probit regression model, the remifentanil EC50 was 3.7 (3.0-4.3) and 2.7 (1.8-2.9) ng/ml in groups M and F, respectively.ConclusionsThe remifentanil EC50 for preventing the moderate to severe injection pain of propofol was higher in males than in females. |
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| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-12T18:22:20Z |
| publishDate | 2012-12-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-cdfab8c090b448cba2b050c6c068d97a2022-12-22T00:16:07ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632012-12-0163650450910.4097/kjae.2012.63.6.5047466The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofolBo-Won Lee0Sang-Hun Kim1Keum-Young So2Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju, Korea.BackgroundPropofol injection pain is an unpleasant experience to patients and its prevalence can be influenced by age and gender. We determined the half maximal effective concentration (EC50) of remifentanil for preventing the microemulsion propofol injection pain in the male and female adult groups.MethodsAfter institutional review board approval, a total of 60 patients were assigned into 2 groups depending on their gender: group M (male, 20-65 yr) and group F (female, 20-65 yr). Anesthesia was induced with propofol and remifentanil, by a target-controlled infusion. Target effect-site concentration (Ce) of propofol and remifentanil for the first patient started at 4.0 ug/ml and 4.0 ng/ml. Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by the Dixon's up-and-down method (DUDM) with an interval of 0.2 ng/ml. After equilibration of plasma and effect site remifentanil concentration, propofol was administered, and the pain responses were observed.ResultsThe remifentanil EC50 was 3.8 ± 0.2 and 2.7 ± 0.2 ng/ml in groups M and F, respectively, by DUDM. From Probit regression model, the remifentanil EC50 was 3.7 (3.0-4.3) and 2.7 (1.8-2.9) ng/ml in groups M and F, respectively.ConclusionsThe remifentanil EC50 for preventing the moderate to severe injection pain of propofol was higher in males than in females.http://ekja.org/upload/pdf/kjae-63-504.pdfgender identitypainpropofolremifentanil |
| spellingShingle | Bo-Won Lee Sang-Hun Kim Keum-Young So The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol Korean Journal of Anesthesiology gender identity pain propofol remifentanil |
| title | The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol |
| title_full | The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol |
| title_fullStr | The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol |
| title_full_unstemmed | The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol |
| title_short | The effect of gender on EC of remifentanil to prevent pain during injection of microemulsion propofol |
| title_sort | effect of gender on ec of remifentanil to prevent pain during injection of microemulsion propofol |
| topic | gender identity pain propofol remifentanil |
| url | http://ekja.org/upload/pdf/kjae-63-504.pdf |
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